{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:41:11Z","timestamp":1773459671129,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3843,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypothesis: The opiate antagonist, naltrexone, will be beneficial in Rett syndrome. Subjects: Twenty\u2010five individuals fulfilling the criteria for Rett syndrome. Method: Randomized, double\u2010blind, placebo\u2010controlled crossover trial with two treatment periods, 4 months each, and an intervening 1\u2010month washout period. Clinical stage, motor and cognitive development, motor\u2013behavioral analysis, neurophysiological parameters (computerized electroencephalographic analysis, breathing characteristics, quantification of stereotyped hand movements, and sleep characteristics), and cerebrospinal fluid \u03b2\u2010endorphin measurements were evaluated at baseline and at the end of each treatment period. Results: Only data from the first period of this study were analyzed due to significant sequence effects in the crossover design. This analysis indicated positive effects on certain respiratory characteristics including decreased disorganized breathing during wakefulness. Four (40%) of the individuals receiving naltrexone progressed one or more clinical stages versus none of the individuals receiving placebo. The adjusted (for baseline value and Rett stage) end of treatment psychomotor test age (Bayley Scales) was significantly higher for the placebo group. There was no significant change for the other parameters. Conclusion: Naltrexone may modify some of the respiratory disturbance in Rett syndrome. Declines in motor function and more rapid progression of the disorder suggest a deleterious effect.<\/jats:p>","DOI":"10.1002\/ana.410350415","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:00:17Z","timestamp":1104595217000},"page":"464-470","source":"Crossref","is-referenced-by-count":61,"title":["Rett syndrome: Controlled study of an oral opiate antagonist, naltrexone"],"prefix":"10.1002","volume":"35","author":[{"given":"Alan K.","family":"Percy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel G.","family":"Glaze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca J.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda 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