{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:24:12Z","timestamp":1790706252345,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3843,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report FK506\u2010induced neurotoxicity in 14 of 44 consecutive patients following orthoptic liver transplantation. In 10 of these 14 patients, postural hand tremors were found in the first weeks following surgery, transient apraxia of speech in 3, and generalized tonic\u2010clonic seizures were noted in 2 patients. Other manifestations included nightmares, agitation, and acute delirium. Reduction of the FK506 dose resulted in resolution of symptoms, but in 1 patient mild speech difficulties and in 3 patients a fine tremor remained. Blood and plasma levels of FK506 were similar in patients with and without neurotoxicity. FK506 neurotoxicity in patients with liver transplantation commonly results in transient neurological manifestations. The incidence of neurotoxicity in FK506 is dramatically reduced in maintenance doses of 0.075 mg\/kg twice a day.<\/jats:p>","DOI":"10.1002\/ana.410350422","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:00:17Z","timestamp":1104595217000},"page":"498-501","source":"Crossref","is-referenced-by-count":138,"title":["FK506\u2010induced neurotoxicity in liver transplantation"],"prefix":"10.1002","volume":"35","author":[{"given":"Eelco F. M.","family":"Wijdicks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell H.","family":"Wiesner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Dahlke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud A. F.","family":"Krom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"2713","article-title":"FK506: historical perspectives","volume":"23","author":"Goto T","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_1_3_2","first-page":"2977","article-title":"Randomized trial of primary liver transplanation under immunosuppression with FK506 vs cyclosporine","volume":"23","author":"Fung J","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91014-3"},{"key":"e_1_2_1_5_2","first-page":"3319","article-title":"The new era of immunosuppressive therapy in autoimmune diseases","volume":"23","author":"Bach JK","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_1_6_2","first-page":"3175","article-title":"Neurologic complications of FK506","volume":"23","author":"Eidelman BH","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_1_7_2","first-page":"3173","article-title":"Similar clinical presentation of neurotoxicity following FK506 and cyclosporine in a liver transplant recipient","volume":"23","author":"Freise CE","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199012000-00028"},{"key":"e_1_2_1_9_2","first-page":"2745","article-title":"FK506: monitoring in plasma or in whole blood?","volume":"23","author":"Beysens AJ","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710013171404"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410350422","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410350422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T14:37:19Z","timestamp":1698158239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410350422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4]]}},"alternative-id":["10.1002\/ana.410350422"],"URL":"https:\/\/doi.org\/10.1002\/ana.410350422","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}