{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:49:42Z","timestamp":1791164982788,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3752,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of early radiotherapy in the treatment of low\u2010grade gliomas is controversial. For this reason the impact of radiotherapy on quality of life was studied in long\u2010term survivors of biopsy\u2010proved low\u2010grade gliomas without signs of tumor recurrence. Twenty patients (age range, 18\u201366 years) had been treated with early radiotherapy; the other 21 patients (age range, 19\u201365 years) had undergone surgery or biopsy only. The interval from diagnosis to testing ranged from 1 to 12 years (mean, 3.5 years). Nineteen patients with low\u2010grade hematological malignancies, surviving 1 to 15 years without central nervous system involvement, served as control subjects. Apart from the neurological and functional status, the patients' cognitive, affective, and psychological status was determined. None of the survivors had significant neurological impairment and the Karnofsky index for them was at least 70. However, more specific examinations of cognitive functions and the affective status (Profile of Mood States) indicated that, compared to the control subjects, the patients with low\u2010grade gliomas had significantly more cognitive disturbances and suffered more frequently from fatigue and depressed moods. The two groups with low\u2010grade gliomas, on the other hand, did not differ significantly on any of these measures. It is concluded that radiotherapy did not cause these disturbances and had no negative impact on quality of life in these patients.<\/jats:p>","DOI":"10.1002\/ana.410360111","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:04:30Z","timestamp":1104595470000},"page":"48-54","source":"Crossref","is-referenced-by-count":244,"title":["Cognitive functions and quality of life in patients with low\u2010grade gliomas: The impact of radiotherapy"],"prefix":"10.1002","volume":"36","author":[{"given":"M. J. B.","family":"Taphoorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Klein","family":"Schiphorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. J.","family":"Snoek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lindeboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"Wolbers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B. M. F.","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"Huijgens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Heimans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-84127-9_5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310413"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310414"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520470106035"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530100108023"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1989.70.6.0853"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-198706000-00028"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850301)55:5<919::AID-CNCR2820550502>3.0.CO;2-4"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.61.4.0665"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900701)66:1<6::AID-CNCR2820660103>3.0.CO;2-F"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90183-V"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-84127-9_20"},{"key":"e_1_2_1_14_2","volume-title":"Radiation injury to the nervous system","author":"Gutin PH","year":"1991"},{"key":"e_1_2_1_15_2","first-page":"105","article-title":"Evaluating the impact of medical care and technologies on the quality of life: a review and critique","volume":"15","author":"Najman JM","year":"1981","journal-title":"Soc Sci Med"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(85)90335-1"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.5.372"},{"key":"e_1_2_1_18_2","volume-title":"Tumors of the central nervous system. Atlas of tumor pathology, section X, fascicles 35 and 36","author":"Kernohan JW","year":"1952"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831201)52:11<2107::AID-CNCR2820521123>3.0.CO;2-X"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02571297"},{"key":"e_1_2_1_21_2","first-page":"191","volume-title":"Evaluation of chemotherapeutic agents","author":"Karnofsky DA","year":"1949"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0054651"},{"key":"e_1_2_1_23_2","volume-title":"Wechsler Intelligence Scale for Children","author":"Wechsler D","year":"1949"},{"key":"e_1_2_1_24_2","volume-title":"L'examen clinique en psychologie","author":"Rey A","year":"1964"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688638708410764"},{"key":"e_1_2_1_26_2","volume-title":"Test d2. Aufmerksamkeitbelastungstest","author":"Brickenkamp R","year":"1978"},{"key":"e_1_2_1_27_2","volume-title":"Administration, norms, and commentary","author":"Spreen O","year":"1981"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500300038006"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1979.00500490051008"},{"key":"e_1_2_1_30_2","volume-title":"Manual for the Profile of Mood States","author":"McNair DM","year":"1971"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.2.172"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198704000-00052"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1990.00530040039017"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410360111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410360111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T12:32:31Z","timestamp":1698150751000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410360111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1002\/ana.410360111"],"URL":"https:\/\/doi.org\/10.1002\/ana.410360111","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}