{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:08:12Z","timestamp":1760980092505},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3752,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Subacute sclerosing panencephalitis (SSPE) is related to \u201cdefective\u201d measles virus or vaccination, though an association with parainfluenza viruses has been reported. SSPE is characterized by a slow, erratic course and elevated cerebrospinal fluid measles titers. An immunocompetent, vaccinated infant, with onset of symptoms in parainfluenza virus season and a catastrophic course is described. Cerebrospinal fluid titers were negative, but postmortem brain had typical SSPE lesions. Patient brain\u2010derived RNA, subjected to reverse transcription followed by polymerase chain reaction yielded polymerase chain reaction products with measles virus but not parainfluenza virus genes. The sequenced fragment revealed multiple mutations, typical for SSPE. SSPE can thus present in infants, with short latency and no cerebrospinal fluid antibodies. Viral genomic analysis may be diagnostic, permitting early therapy.<\/jats:p>","DOI":"10.1002\/ana.410360120","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:04:30Z","timestamp":1104595470000},"page":"103-108","source":"Crossref","is-referenced-by-count":21,"title":["Subacute sclerosing panencephalitis in an infant: Diagnostic role of viral genome analysis"],"prefix":"10.1002","volume":"36","author":[{"given":"Tallie Z.","family":"Baram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Gonzalez\u2010Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong\u2010De","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dapeng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floyd H.","family":"Gilles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Marvin D.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hahn T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"145","volume-title":"Infections of the central nervous system","author":"Asher DM","year":"1991"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1979.00500460044004"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(89)90045-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(77)90012-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(82)90073-X"},{"key":"e_1_2_1_7_2","first-page":"257","article-title":"Parainfluenza encephalitis with predominant clinical symptoms of status epilepticus","volume":"55","author":"Wender M","year":"1980","journal-title":"Pediatr Pol."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(90)90063-7"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92228-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.488"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1128\/jcm.29.5.945-952.1991","article-title":"Detection of rubella virus gene sequences by enzymatic amplification and direct sequencing of amplified DNA","volume":"29","author":"Eggerding FA","year":"1991","journal-title":"J Clin Microbiol."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890300402"},{"key":"e_1_2_1_13_2","first-page":"297","article-title":"Neurological diseases associated with viral and Mycoplasma pneumoniae infections","volume":"58","author":"Assaad F","year":"1980","journal-title":"Bull WHO."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197605000-00003"},{"key":"e_1_2_1_15_2","first-page":"454","article-title":"Sur un cas d'encephalite subaigue a inclusions. 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