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Recently, the pathophysiology underlying several types of nystagmus and saccadic oscillations was better defined by the development of animal models and by experimental pharmacological studies. Despite this, few reliable therapies are currently available for these abnormal eye movements. In clinical studies, a number of drugs reportedly helped individual patients, but few drugs have been subjected to double\u2010blind trials. An alternative approach to pharmacological suppression of abnormal eye movements is optical stabilization of images on the retina, which is helpful in selected patients. Weakening of the extraocular muscles, using botulinum toxin or surgery, is prone to cause diplopia and may induce plastic\u2010adaptive changes that render the effect temporary. In some patients, treatment of an underlying condition, such as the Arnold\u2010Chiari malformation, reduces nystagmus and improves vision. There is a need for multicenter trials to evaluate systematically potential treatments of abnormal eye movements that impair vision.<\/jats:p>","DOI":"10.1002\/ana.410360204","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:06:26Z","timestamp":1104595586000},"page":"129-141","source":"Crossref","is-referenced-by-count":45,"title":["Treatment of abnormal eye movements that impair vision: Strategies based on current concepts of physiology and pharmacology"],"prefix":"10.1002","volume":"36","author":[{"given":"R. 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