{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:27:11Z","timestamp":1782300431755,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3660,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1994,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the apolipoprotein E (apo E) genotypes in 47 patients with late\u2010onset sporadic Alzheimer's disease (mean age at onset \u00b1 standard deviation, 72.2 \u00b1 6.4 years), 8 with late\u2010onset familial Alzheimer's disease (75.5 \u00b1 5.1 years), 18 with early\u2010onset sporadic Alzheimer's disease (52.8 \u00b1 4.7 years), and 10 with early\u2010onset familial Alzhemer's disease (52.0 \u00b1 6.8 years) in Japan and compared them with genotypes in control subjects. In late\u2010onset sporadic Alzheimer's disease, apo E\u2010\u03b54 frequency increased significantly (\u03b54 frequency: 0.34 vs 0.095 in controls, <jats:italic>p<\/jats:italic> &lt; 0.0001), and the odds ratio, which represents the strength of association between Alzheimer's disease and apo E\u2010\u03b54 gene (3 [95% confidence interval, 2\u20136] in one dose; 43 [95% confidence interval, 12\u2013154] in two doses). This study also suggested that apo E\u2010\u03b54 is associated with both late\u2010onset (\u03b54: 0.31) and early\u2010onset familial Alzheimer's disease (\u03b54: 0.35). In contrast, we found no association between apo E\u2010\u03b54 and early\u2010onset sporadic Alzheimer's disease (\u03b54: 0.08). These results indicate that the risk of developing late\u2010onset sporadic Alzheimer's disease is markedly dependent on the dose of apo E\u2010\u03b54, while apo E\u2010\u03b54 does not appear to be a major risk factor for early\u2010onset sporadic Alzheimer's disease.<\/jats:p>","DOI":"10.1002\/ana.410360416","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:06:34Z","timestamp":1104595594000},"page":"656-659","source":"Crossref","is-referenced-by-count":52,"title":["Dose\u2010dependent association of apolipoprotein e allele \u03b54 with late\u2010onset, sporadic Alzheimer's disease"],"prefix":"10.1002","volume":"36","author":[{"given":"Toshihiro","family":"Yoshizawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiko","family":"Yamakawa\u2010Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Komatsuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadao","family":"Arinami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ei'ichi","family":"Oguni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Mizusawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin'ichi","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Hamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/353844a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1925564"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1411576"},{"key":"e_1_2_1_6_2","first-page":"1034","article-title":"Linkage studies in familial Alzheimer's disease: evidence for chromosome 19 linkage","volume":"48","author":"Pericak\u2010Vance MA","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1977"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1467"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91705-Q"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91728-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(93)90147-Q"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-76891-0_10"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92823-K"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91728-5"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410360416","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410360416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T03:45:50Z","timestamp":1698205550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410360416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,10]]}},"alternative-id":["10.1002\/ana.410360416"],"URL":"https:\/\/doi.org\/10.1002\/ana.410360416","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10]]}}}