{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:05:55Z","timestamp":1790363155643,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3599,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The 4\u2010kd amyloid \u03b2 prrotein (A\u03b2) deposited as amyloid in Alzheimer's disease (AD) is produced and released by normal proteolytic processing of the amyloid \u03b2 protein precursor (\u03b2APP) and is readily detected in cerebrospinal fluid (CSF). Here, we present the levels of A\u03b2 in CSF from a total of 95 subjects, including 38 patients with AD, 14 with early\u2010onset AD and 24 with late\u2010onset AD, 25 normal control subjects, and 32 patients with other neurological diseases. The level of A\u03b2 decreased with normal aging, and there was a significant elevation in the level of A\u03b2 in the CSF of early\u2010onset AD patients (4.14 \u00b11.37 pmol\/ml, p &lt; 0.01). Neither Mini\u2010Mental State nor Functional Assessment Staging were correlated with the amount of A\u03b2 in the CSF. The A\u03b2\/secreted form of \u03b2APP ration was elevated, but the level of \u03b1;1\u2010antichymotrypsin in the CSF did not correlate with the level of CSF A\u03b2 in early\u2010onset AD patients. Thus, the level of A\u03b2 in the CSF is elevated in early\u2010onset AD patients and is suggested to be correlated with the pathology in the brain that characterizes AD.<\/jats:p>","DOI":"10.1002\/ana.410360616","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:10:57Z","timestamp":1104595857000},"page":"903-911","source":"Crossref","is-referenced-by-count":77,"title":["Amyloid \u03b2 protein levels in cerebrospinal fluid are elevated in early\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"36","author":[{"given":"Tamiko","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Harigaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsunori","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hosoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobun T.","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian M.","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd 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