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In the local session, lidocaine gel was applied to the painful skin area. In the remote session, lidocaine gel was applied to mirror\u2010image skin. In the placebo session, vehicle was applied bilaterally. For cranial PHN, gel was applied without occlusion for 8 hours. For limb or torso PHN, gel was applied under occlusion for 24 hours. The 16 subjects with cranial PHN reported pain relief significantly favoring local drug application at 30 minutes, 2, 4, and 8 hours. The 23 subjects with torso or limb PHN reported significantly lower pain intensity with local drug application at 8 hours and both pain relief and reduced pain intensity at 24 hours. Remote lidocaine application to mirror\u2010image skin was no different from placebo. No systemic adverse effects were reported and blood levels did not exceed 0.6 \u03bcg\/ml. Topical application of 5% lidocaine gel relieves PHN pain by a direct drug action on painful skin.<\/jats:p>","DOI":"10.1002\/ana.410370216","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:13:02Z","timestamp":1104595982000},"page":"246-253","source":"Crossref","is-referenced-by-count":198,"title":["Topical lidocaine gel relieves postherpetic neuralgia"],"prefix":"10.1002","volume":"37","author":[{"given":"Michael C.","family":"Rowbotham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela S.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard 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