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We studied the pathogenic role of anti\u2010GM<jats:sub>1<\/jats:sub> antibody using the petroleum jelly\u2013gap voltage clamp technique on isolated single myelinated rat nerve fibers. Anti\u2010GM<jats:sub>1<\/jats:sub> antisera were obtained from rabbits immunized with GM<jats:sub>1<\/jats:sub> ganglioside. Extracellularly applied anti\u2010GM<jats:sub>1<\/jats:sub> antisera without complement activity increased both the rate of rise and the amplitude of the K<jats:sup>+<\/jats:sup> current elicited by step depolarization, with little effect on Na<jats:sup>+<\/jats:sup> current. In the presence of active complement, however, anti\u2010GM<jats:sub>1<\/jats:sub> antibodies decreased the Na<jats:sup>+<\/jats:sup> current, and caused a progressive increase of nonspecific leakage current. Neither complement alone nor complement\u2010supplemented antisera from which anti\u2010GM<jats:sub>1<\/jats:sub> antibodies were depleted by affinity chromatography had any effect on ionic current. These observations indicate that anti\u2010GM<jats:sub>1<\/jats:sub> antibodies themselves can uncover K<jats:sup>+<\/jats:sup> channels in the paranodal region, while anti\u2010GM<jats:sub>1<\/jats:sub> antibodies bound to the nodal membrane in the presence of complement may form antibody\u2010complement complexes that block Na<jats:sup>+<\/jats:sup> channels and disrupt the membrane at the node of Ranvier.<\/jats:p>","DOI":"10.1002\/ana.410370405","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:16:47Z","timestamp":1104596207000},"page":"436-442","source":"Crossref","is-referenced-by-count":201,"title":["Antibodies against GM<sub>1<\/sub> ganglioside affect K<sup>+<\/sup> and NA<sup>+<\/sup> currents in isolated rat myelinated nerve 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