{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T14:37:07Z","timestamp":1770475027783,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3448,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It was suggested that in contrast to the E4 allele, the E2 allele of the apolipoprotein E gene (APOE *2) has a protective effect for late\u2010onset Alzheimer's disease and early\u2010onset Alzheimer's disease (EOAD). We studied the role of the APOE*2 allele in the pathogenesis of EOAD in a Dutch population\u2010based study of 175 probable EOAD patients with onset age at or before 65 years and 532 age\u2010matched controls. In our population, there was no evidence for a protective effect of the APOE*2 allele on the risk of EOAD. However, our data show that among EOAD patients, survival for APOE*2 carriers was significantly reduced. When restricting the analysis to patients ascertained early after diagnosis at a stage of disease when mortality is low, our data suggest an increased risk of EOAD for subjects with APOE2E2, APOE2E3, APOE3E4, and APOE4E4 genotypes.<\/jats:p>","DOI":"10.1002\/ana.410370510","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:17:05Z","timestamp":1104596225000},"page":"605-610","source":"Crossref","is-referenced-by-count":82,"title":["The apolipoprotein E \u03b52 allele is associated with an increased risk of early\u2010onset alzheimer's disease and a reduced survival"],"prefix":"10.1002","volume":"37","author":[{"given":"Cornelia M.","family":"van Duijn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"de 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