{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:04:54Z","timestamp":1791068694976,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3417,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We retrospectively compared ictal technetium 99m hexamethylpropyleneamineoxime single\u2010photon emission computed tomography (SPECT) and interictal <jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography (PET) in 35 patients with well\u2010lateralized temporal lobe epilepsy (TLE). Based on SPECT scans the two observers correctly lateralized seizure foci with certainty in 89% of patients; interobserver agreement was excellent. Both observers incorrectly lateralized the seizure focus on two SPECT scans; one error was explained by rapid electroencephalographic spread to the contralateral side and for the other patient, isotope was injected during a brief aura. Based on PET scans, observers correctly lateralized the foci with certainty in 63% and with lesser confidence in 83%; four incorrect lateralizations were made by one observer and none by the other. PET interobserver disagreement was explained by differences between observers in weighting the relative hypometabolism in medial and lateral temporal regions. The detection rate for PET was lower in the absence of structural imaging abnormalities (60 vs 87%). PET yielded correct lateralizations in the 2 patients for whom SPECT interpretation was difficult. We conclude that both ictal SPECT and interictal PET are sensitive methods for the lateralization of TLE, but SPECT can be interpreted with greater certainty and is more sensitive when magnetic resonance imaging findings are negative. False lateralization is rare with ictal SPECT and can be explained when interpreted in conjunction with electroclinical data. Both investigations have complementary roles when localization is difficult.<\/jats:p>","DOI":"10.1002\/ana.410370607","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:58:48Z","timestamp":1104587928000},"page":"738-745","source":"Crossref","is-referenced-by-count":123,"title":["Comparison of ictal SPECT and interictal PET in the presurgical evaluation of temporal lobe epilepsy"],"prefix":"10.1002","volume":"37","author":[{"given":"Susan S.","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel F.","family":"Berkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore U.","family":"Berlangieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary F.","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri J.","family":"Tochon\u2010Danguy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. John","family":"McKay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"251","volume-title":"Epilepsy surgery","author":"Berkovic SF","year":"1991"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.11.1670"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150735"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220407"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140406"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410060502"},{"key":"e_1_2_1_8_2","first-page":"549","article-title":"Serial studies of cerebral blood flow using 99mTc\u2010HMPAO: a comparison with 133Xe","volume":"8","author":"Andersen AR","year":"1987","journal-title":"Nucl Med Commun"},{"key":"e_1_2_1_9_2","first-page":"191","article-title":"Technetium 99m\u2010d,l\u2010HM\u2010PAO: a new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion","volume":"28","author":"Neirinckx RD","year":"1987","journal-title":"J Nucl Med"},{"key":"e_1_2_1_10_2","first-page":"1595","article-title":"Regional cerebral blood flow imaging: a quantitative comparison of technetium 99m HMPAO SPECT with C15O2 PET","volume":"31","author":"Gemmell HG","year":"1990","journal-title":"J Nucl Med"},{"key":"e_1_2_1_11_2","volume-title":"Research progress in epilepsy","author":"Engel J","year":"1983"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1984.tb05651.x"},{"key":"e_1_2_1_13_2","first-page":"385","volume-title":"Comprehensive epileptology","author":"Engel J","year":"1990"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410120603"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080403"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310613"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.10.891"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00181061"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410260512"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.7.1096"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314081"},{"key":"e_1_2_1_22_2","first-page":"262","article-title":"Positron emission tomography and single photon emission tomography in epilepsy: comparison of cerebral blood flow and glucose metabolism","volume":"28","author":"Theodore WH","year":"1990","journal-title":"Ann Neurol"},{"key":"e_1_2_1_23_2","first-page":"666","article-title":"Ictal SPECT using 99mTc\u2010HMPAO: methods for rapid preparation and optimal deployment of tracer during spontaneous seizures","volume":"34","author":"Newton MR","year":"1993","journal-title":"J Nucl Med"},{"key":"e_1_2_1_24_2","first-page":"1688","article-title":"Visual and quantitative analysis of interictal SPECT with Tc\u201099m HMPAO in temporal lobe epilepsy","volume":"32","author":"Rowe CC","year":"1991","journal-title":"J Nucl Med"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410120604"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"e_1_2_1_27_2","first-page":"243","volume-title":"Epilepsy surgery","author":"Henry TR","year":"1991"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(91)90010-D"},{"key":"e_1_2_1_29_2","first-page":"1017","article-title":"18FDGPET scans in paretal lobe epilepsy","volume":"33","author":"Swartz BE","year":"1992","journal-title":"J Nucl Med"},{"key":"e_1_2_1_30_2","first-page":"553","volume-title":"Surgical treatment of the epilepsies","author":"Delgado\u2010Escueta AV","year":"1987"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410370607","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410370607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410370607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:09:57Z","timestamp":1698361797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410370607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,6]]}},"alternative-id":["10.1002\/ana.410370607"],"URL":"https:\/\/doi.org\/10.1002\/ana.410370607","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]}}}