{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:56:05Z","timestamp":1791276965856,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3417,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Elevated plasma levels of interleukin\u20106 (IL\u20106), a key regulator of the acute phase response that includes increased fibrinogen synthesis, have recently been detected in patients with acute stroke. Nevertheless, the role of the acute phase response in stroke has been controversial, with some studies suggesting that preexisting infection accounts for most of the acute phase response. Increased IL\u20106 could signal the involvement of antiinflammatory activity, since IL\u20106 stimulates the production of endogenous antiinflammatory mediators such as interleukin\u20101 receptor antagonist (IL\u20101RA). To better understand the interaction of pro\u2010 and antiinflammatory acute phase processes in brain infarction, plasma levels of IL\u20101RA, IL\u20106, and acute phase proteins including fibrinogen and c\u2010reactive protein (CRP) were measured within 4 \u00b1 2 days of onset in 50 patients with acute ischemic stroke and in 20 age\u2010matched healthy controls. After excluding patients with evidence of infection, both IL\u20101RA and IL\u20106 were significantly elevated in stoke patients compared with controls (<jats:italic>p<\/jats:italic>&lt;0.0001). IL\u20101RA and IL\u20106 were both significantly correlated with levels of CRP, <jats:italic>p<\/jats:italic>&lt;0.05 and <jats:italic>p<\/jats:italic>&lt;0.001, respectively, but not with each other. Levels of IL\u20106 and IL\u20101RA, together with fibrinogen and CRP were higher in patients with infarcts of greater than 3 cm and lowest in patients with lacunar syndromes. Detection of increased peripheral levels of IL\u20101RA, IL\u20106, and additional acute phase reactants, including CRP, in acute stroke uncomplicated by infection suggests that an acute phase response to brain infarction occurs and that the magnitude of this response may be related to the volume of infarcted brain.<\/jats:p>","DOI":"10.1002\/ana.410370614","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:58:48Z","timestamp":1104587928000},"page":"800-805","source":"Crossref","is-referenced-by-count":171,"title":["Interleukin\u20106 and interleukin\u20101 receptor antagonist in acute stroke"],"prefix":"10.1002","volume":"37","author":[{"given":"Nancy B.","family":"Beamer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Coull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne M.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Samantha","family":"Hazel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny R.","family":"Silberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198408233110804"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1001\/jama.1987.03400090067035","article-title":"The Framingham study: fibrinogen and risk of cardiovascular disease","volume":"258","author":"Kannel WB","year":"1987","journal-title":"JAMA"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-12-199306150-00008"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-5-371"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.8.1133"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.1.63"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.8.1004"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90289-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60429-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041540305"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.9.1367"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000319085"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.1.113.113"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114622"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(92)90033-T"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.8.983"},{"key":"e_1_2_1_18_2","unstructured":"STATA version 3.1. Los Angeles: The Computing Resource Center 1993"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199401000-00026"},{"key":"e_1_2_1_20_2","first-page":"739","article-title":"Modulation of systemic interleukin\u20106 by central interleukin\u20101","volume":"265","author":"De Simoni MG","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/1043-4666(92)90078-6"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.5.1629"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.4049\/jimmunol.151.11.6370","article-title":"Effects of IL\u201013 on phenotype, cytokine production, and cytotoxic function of human monocytes: comparison with IL\u20104 and modulation by IFN\u2010gamma or IL\u201010","volume":"151","author":"Waal De","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_1_24_2","first-page":"308","article-title":"Cytokine and superoxide production in clinical stroke","volume":"36","author":"Clark WM","year":"1994","journal-title":"Ann Neurol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1993.11740119"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0923-2494(92)80051-L"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108153250704"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.76"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01541172"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310213291708"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410370614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410370614","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410370614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:09:23Z","timestamp":1698361763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410370614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,6]]}},"alternative-id":["10.1002\/ana.410370614"],"URL":"https:\/\/doi.org\/10.1002\/ana.410370614","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]}}}