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Treatment included high\u2010dose cytosine arabinoside, cyclophosphamide, and total body irradiation prior to the BMT. The children developed a progressively worsening encephalopathy and parkinsonian features, characterized by resting tremor, cogwheel rigidity, and masklike facies. Neuroimaging studies showed cerebellar, cerebral, and basal ganglia atrophy, as well as frontal and temporal lobe white matter involvement. Two of the 3 patients recovered, although 1 has residual intellectual impairment. The third succumbed to non\u2013central nervous system Epstein\u2010Barr virus\u2013lymphoproliferative disease and had autopsy\u2010confirmed leukoenephalopathy.<\/jats:p>","DOI":"10.1002\/ana.410370616","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:58:48Z","timestamp":1104587928000},"page":"810-814","source":"Crossref","is-referenced-by-count":47,"title":["Encephalopathy with parkinsonian features in children following bone marrow transplantations and high\u2010dose amphotericin B"],"prefix":"10.1002","volume":"37","author":[{"given":"Stephen H.","family":"Mott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Packer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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