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In comparison with data obtained from the normal control subjects, we found significantly Decemberreased ligand influx in the cerebellum and brainstem of multiple system atrophy patients of the olivopontocerebellar atrophy type and in patients with sporadic olivopontocerebellar atrophy, but not in patients with multiple system atrophy of the Shy\u2010Drager syndrome type. Despite these differences in ligand influx, benzodiazepine binding was largely preserved in the cerebral hemispheres, basal ganglia, thalamus, cerebellum, and brainstem in patients with multiple system atrophy of both types as well as those with sporadic or dominantly inhierited olivoponto\u2010cerebellar atrophy as compared with normal control subjects. The finding of relative preservation of benzodiazepine receptors indicates that these sites are available for pharmacological therapy in these disorders.<\/jats:p>","DOI":"10.1002\/ana.410380209","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:25:54Z","timestamp":1104596754000},"page":"176-185","source":"Crossref","is-referenced-by-count":22,"title":["Benzodiazepine receptor binding in cerebellar degenerations studied with positron emission tomography"],"prefix":"10.1002","volume":"38","author":[{"given":"Sid","family":"Gilman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Koeppe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Junck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen J.","family":"Kluin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Lohman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy T.","family":"St. Laurent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00449811"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(89)90001-5"},{"key":"e_1_2_1_4_2","first-page":"59","article-title":"GABAA receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system","volume":"3","author":"Olsen RW","year":"1990","journal-title":"J Chem Neuroanat"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00972207"},{"key":"e_1_2_1_6_2","first-page":"442","article-title":"Influences of ions, enzymes and detergents on gamma\u2010aminobutyric acid receptor binding in synaptic membranes of rat brain","volume":"13","author":"Enna SJ","year":"1977","journal-title":"Mol Pharmacol"},{"key":"e_1_2_1_7_2","first-page":"217","article-title":"Gamma\u2010aminobutyric acid receptor binding in mammalian brain: heterogeneity of binding sites","volume":"19","author":"Olsen RW","year":"1981","journal-title":"Mol Pharmacol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90249-8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)91034-9"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.1.670"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb05284.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(86)90317-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-708X(84)90215-1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1991.130"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300506"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","unstructured":"QuinnN. 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