{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:20:47Z","timestamp":1790468447606,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3295,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of the apolipoprotein E (APOE) \u03f54 allele on age of onset was analyzed in two groups of families with early\u2010onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early\u2010onset non\u2010VG families showing evidence of linkage to chromosome 14. The \u03f54 allele did not have a detectable effect on age of onset in either group. This finding suggests some forms of early\u2010onset familial AD are not modifiable by APOE status, or that AD can be caused by APOE\u2010independent pathways.<\/jats:p>","DOI":"10.1002\/ana.410380420","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:27:23Z","timestamp":1104596843000},"page":"678-680","source":"Crossref","is-referenced-by-count":52,"title":["Apolipoprotein E genotypes and age of onset in early\u2010onset familial Alzheimer's disease"],"prefix":"10.1002","volume":"38","author":[{"given":"Ephrat","family":"Levy\u2010Lahad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amnon","family":"Lahad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Wijsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas 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