{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T10:54:30Z","timestamp":1759056870081},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3234,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti\u2014myelin basic protein, anti\u2014proteolipid protein, and anti\u2014myelin basic protein peptide (amino acid residues 1\u201320, 63\u201388, and 89\u2013101) antibody\u2014secreting cells were studied in 20 patients with idiopathic optic neuritis, 20 with optic neuritis as part of multiple sclerosis, and 20 neurological control subjects. Antibody\u2010secreting cells were enumerated with an immunospot assay; the relative binding affinity of the antibodies was estimated by elution with thiocyanate. Patients with optic neuritis had more anti\u2014myelin basic protein and anti\u2014proteolipid protein antibodies than did control subjects (both <jats:italic>p<\/jats:italic> &lt; 0.05); there was no difference between idiopathic optic neuritis and optic neuritis as a symptom of multiple sclerosis. Presence of the multiple sclerosis\u2014associated DRB1 1501 gene was not associated with preferential synthesis of high\u2010affinity antibodies reactive with a single myelin basic protein peptide or with preferential synthesis of either anti\u2014myelin basic protein or anti\u2014proteolipid protein antibodies. The results demonstrate a potential for intrathecal synthesis of both anti\u2014myelin basic protein and anti\u2014proteolipid protein antibodies of high apparent affinity in patients with optic neuritis.<\/jats:p>","DOI":"10.1002\/ana.410380616","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:29:11Z","timestamp":1104596951000},"page":"943-950","source":"Crossref","is-referenced-by-count":24,"title":["Acute optic neuritis: Myelin basic protein and proteolipid protein antibodies, affinity, and the HLA system"],"prefix":"10.1002","volume":"38","author":[{"given":"F.","family":"Sellebjerg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. O.","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Frederiksen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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