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We used a 2.1\u2010T magnetic resonance imager\u2010spectrometer and an 8\u2010cm surface coil to measure a 13.5\u2010cm<jats:sup>3<\/jats:sup> volume in the occipital cortex. GABA levels were measured in 14 patients enrolled in an open\u2010label trial of gabapentin. GABA was elevated in patients taking gabapentin compared with 14 complex partial epilepsy patients, matched for antiepileptic drug treatment. Brain GABA levels appeared to be higher in patients taking high\u2010dose gabapentin (3,300\u20133,600 mg\/day) than in those taking standard doses (1,200\u20132,400 mg\/ day). 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