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Pharmacologic concentrations of IVIg, ranging from 0.1 \u03bcg\/ml to 100 mg\/ml, inhibited anti\u2010GM, binding to its target antigen from 26 \u00b1 3 to 71 \u00b1 7%, respectively, in a dose\u2010dependent manner. A similar inhibition of binding was also observed with IVIg F(ab\u2032)<jats:sub>2<\/jats:sub> fragments. These findings provide a possible mechanism for the clinical efficacy of IVI g in motor neuropathies.<\/jats:p>","DOI":"10.1002\/ana.410390121","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:31:43Z","timestamp":1104597103000},"page":"136-139","source":"Crossref","is-referenced-by-count":41,"title":["Intravenous \u03b3\u2010globulin inhibits binding of anti\u2010GM1 to its taget antigen"],"prefix":"10.1002","volume":"39","author":[{"given":"Ummekalsoom","family":"Malik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Oleksowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Normarl","family":"Larov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Cardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.7.1278"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280312"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.3_Part_1.537"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1994.00540210031010"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.3_Part_1.429"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1182\/blood.V74.7.2414.2414","article-title":"Inhibition of autoantibody binding to platelet glycoprotein IIb\/IIIa by anti\u2010 idioprypic anribodies in intravenous gammaglobulin","volume":"74","author":"Berchtold P","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(91)80147-E"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(89)90036-2"},{"key":"e_1_2_1_10_2","first-page":"603","article-title":"Pepsin digestion of human G\u2010mycloma proteins of different subclasses. The characteristic features of pepsin cleavage as a function of time","volume":"7","author":"Turner MW","year":"1970","journal-title":"Clin Enp Immunol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198911000-00006"},{"key":"e_1_2_1_12_2","first-page":"18","article-title":"Antibodies to glycoconjugates in neurologic disease","volume":"4","author":"Latov N","year":"1990","journal-title":"Clin Aspects Autoimmun"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1989.tb00031.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1994.tb00861.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115643"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410390121","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410390121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T18:28:19Z","timestamp":1698344899000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410390121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["10.1002\/ana.410390121"],"URL":"https:\/\/doi.org\/10.1002\/ana.410390121","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1]]}}}