{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:38:52Z","timestamp":1776904732777,"version":"3.51.2"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3112,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the expression of Fas antigen and Bcl\u20102 protein in thymic tissue surgically resected from 10 patients with myasthenia gravis, using immunocytochemical techniques. Histologically, thymic tissues from 7 myasthenia gravis patients showed hyperplasia, while 3 other patients had thymomas. In hyperplastic thymic tissue, immunoreactivity for Fas antigen was observed mainly in the network of medullary epithelial cells. In contrast, expression of Fas antigen was rare in the cortex. Fas antigen was also detected to some degree in thymoma tissue from 3 patients. Bcl\u20102 protein was highly expressed in the medullary thymocytes in the hyperplastic thymic tissue, whereas its staining was quite low in myasthenia gravis thymomas. The number of Bcl\u20102\u2010positive thymocytes in the medulla was significantly greater in the hyperplastic myasthenia gravis thymic tissue than in the control thymic tissue. These findings suggest that Bcl\u20102 protein may be upregulated in the myasthenia gravis thymus and that this phenomenon may be related to impaired apoptotic cell death of autoreactive thymocytes in myasthenia gravis.<\/jats:p>","DOI":"10.1002\/ana.410390414","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:33:31Z","timestamp":1104597211000},"page":"521-528","source":"Crossref","is-referenced-by-count":20,"title":["Upregulation of Bcl\u20102 protein in the myasthenic thymus"],"prefix":"10.1002","volume":"39","author":[{"given":"Jun\u2010ichi","family":"Onodera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneshige","family":"Tobita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Oouchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuto","family":"Itoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90568-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/332040a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.002531"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/372100a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90614-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.5.1747"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(92)90187-T"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/356314a0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90361-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90362-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.15.7003"},{"key":"e_1_2_1_13_2","first-page":"225","article-title":"Expression of the bcl\u20102 oncogene protein is not specific for the 14;18 chromosomal translocation","volume":"137","author":"Pezzella F","year":"1990","journal-title":"Am J Parhol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.10.1639"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90236-A"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.16.6961"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1182\/blood.V81.2.293.293","article-title":"Topographical dissociation of BCL\u20102 messenger RNA and protein expression in human lymphoid tissues","volume":"8","author":"Chleq\u2010Deschanips CM","year":"1993","journal-title":"Blood"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2787530"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"10709","DOI":"10.1016\/S0021-9258(19)50076-X","article-title":"Purification and molecular cloning of the APO\u20101 cell surface antigen, a member of the tumor necrosis factor\/nerve growth factor receptor superfamily: sequence identity with the Fas antigen","volume":"267","author":"Oehm A","year":"1992","journal-title":"J Biol Chem"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.148.4.1274"},{"key":"e_1_2_1_21_2","first-page":"415","article-title":"Constitutive and induced expression of APO\u20101, a new member of the nerve growth facror\/tumor necrosis factor receptor superfamily, in normal and neoplastic cells","volume":"69","author":"Leith\u00e4user F","year":"1933","journal-title":"Lab Invest"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(94)90103-1"},{"key":"e_1_2_1_23_2","first-page":"3450","article-title":"Selection of the T cell receptor repertoire in Ipr mice","volume":"151","author":"Herron LR","year":"1993","journal-title":"J lmmunol"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90066-G"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8303290"},{"key":"e_1_2_1_26_2","first-page":"6565","article-title":"Antisense\u2010mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phos\u2010phorothioare oligodeoxynucleotides","volume":"50","author":"Reed JC","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4049\/jimmunol.151.1.83","article-title":"Bcl\u20102 protooncogene expression during human T cell development: evidence for biphasic regulation","volume":"151","author":"Gratiot\u2010Deans J","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_1_28_2","first-page":"115","article-title":"Developmental regulation of bcl\u20102 expression in the thymus","volume":"81","author":"Moore NC","year":"1994","journal-title":"Immunology"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.3.835"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.2.323"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.2.621"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(82)90035-2"},{"key":"e_1_2_1_33_2","first-page":"184","article-title":"The immunohistology of the thymus in myasthenia gravis","volume":"117","author":"Kornstein MJ","year":"1984","journal-title":"Am J Pathol"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.7.1856.1856"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270213"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270610"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410390414","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410390414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:51:59Z","timestamp":1695880319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410390414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["10.1002\/ana.410390414"],"URL":"https:\/\/doi.org\/10.1002\/ana.410390414","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4]]}}}