{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:25:45Z","timestamp":1791116745399,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":3021,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have investigated striatal dopamine D1 and D2 receptor binding in asymptomatic subjects from Huntington's disease (HD) families using positron emission tomography. Nineteen adult subjects at risk of developing HD were scanned with <jats:sup>11<\/jats:sup>C\u2010SCH 23390 and <jats:sup>11<\/jats:sup>C\u2010raclopride to calculate the D1 and D2 receptor binding potential, respectively. Eight of the 19 were shown to have the HD mutation; of these, 4 subjects had significant reductions in striatal dopamine receptor binding. Abnormalities were more common in older subjects and were not correlated with the size of the HD mutation. There was a strong coefficient of correlation between individual levels of striatal D1 and D2 binding in subjects with the mutation. Of 6 other cases with a 50% risk of carrying the HD gene, 1 showed subclinical loss of caudate and putamen D2 binding. Our study suggests that both striatal D1 and D2 dopamine receptors are lost in parallel from both cauudate and putamen in presymptomatic HD and that dopamine receptor binding provides a sensitive means of detecting subclinical striatal dysfunction.<\/jats:p>","DOI":"10.1002\/ana.410400110","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:46:58Z","timestamp":1104590818000},"page":"49-54","source":"Crossref","is-referenced-by-count":166,"title":["Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease"],"prefix":"10.1002","volume":"40","author":[{"given":"R. A.","family":"Weeks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Piccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_1_2_2","first-page":"1","volume-title":"Movement disorders 3","author":"Flaherty AW","year":"1994"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005033221807"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310412"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870080303"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90103-S"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90022-1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90023-X"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90355-C"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.3.689"},{"issue":"4","key":"e_1_2_1_11_2","first-page":"A335","article-title":"Brain glucose metabolim and striatal dopamine receptor density in subjects genetically at risk for Huntington's disease (HD) measured with positron emission tomography (PET)","volume":"43","author":"Antonini A","year":"1993","journal-title":"Neurology"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92208-X"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.12.1036"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1109\/23.12819"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/37\/8\/002"},{"key":"e_1_2_1_16_2","first-page":"9","article-title":"A software system for interactive and quantitative analysis of biomedical images","volume":"14","author":"Robb RA","year":"1991","journal-title":"Australas Phys Eng Sci Med"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150302"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199601000-00005"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-387"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198511000-00003"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199501000-00013"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.15.5733"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90303-5"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.21.10178"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90448-3"},{"key":"e_1_2_1_26_2","first-page":"473","article-title":"Functional striatal grafts: correlations between positron emission tomography in vivo, graft survival, and recovery of reaching behaviour","volume":"20","author":"Fricker RA","year":"1994","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/103.1.179"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/97.1.457"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/ana.410240221","article-title":"Cerebrospinal Fluid, homovanillic acid, and parkinsonism in Huntington's disease","volume":"24","author":"Kurlan R","year":"1988","journal-title":"Ann Neurol"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.59"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.5.823"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410400110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410400110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T17:28:05Z","timestamp":1695835685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410400110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["10.1002\/ana.410400110"],"URL":"https:\/\/doi.org\/10.1002\/ana.410400110","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}