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Recent biochemical and molecular biological studies have identified the microtubule\u2010binding protein tau as the predominant component of these and related inclusions, and have provided powerful new reagents for the study of neurodegenerative diseases. Several diseases previously considered distinct pathophysiological entities contain similar tau\u2010immunoreactive lesions, but qualitative and regional anatomical differences in vulnerability can differentiate the disorders. Comparison of tau\u2010immunoreactive lesions in three relatively uncommon neurodegenerative diseases\u2014progressive supranuclear palsy, Pick's disease, and corticobasal degeneration\u2014illustrates the types of analyses that demonstrate unexpeceted pathological similarities, but also fundamental differences between these disorders. These results have important implications for the differential diagnosis of disorders containing tau\u2010immunoreactive lesions, including Alzheimer's disease.<\/jats:p>","DOI":"10.1002\/ana.410400204","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:47:14Z","timestamp":1104590834000},"page":"139-148","source":"Crossref","is-referenced-by-count":215,"title":["Neurodegenerative disorders with extensive tau pathology: A comparative study and review"],"prefix":"10.1002","volume":"40","author":[{"given":"Mel B.","family":"Feany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis 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