{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:46:14Z","timestamp":1773060374457,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2929,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1996,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The polymorphism of HLA\u2010DRBI, \u2010DRB3, and \u2010DRB5 genes as well as magnetic resonance images of the brain and spinal cord were studied in 57 Japanese patients with multiple sclerosis (MS). Twenty\u2010three patients clinically displayed selective involvement of the optic nerve and spinal cord and were classified as having Asian\u2010type MS. Patients with Asian\u2010type MS had fewer brain lesions shown gy magnetic resonance imaging, but more gadolinium\u2010enhanced spinal cord lesions than did patients with Western\u2010type MS (47% vs 17%). Fruthermore, the DR2\u2010associated DRBI1501 allele and DRB50101 allele were associated with Western\u2010type MS (41.2%), but not with either Asian\u2010type MS (0%) or healthy control subjects (14.2%). Heterogeneity inthe immunogenetic background and in the magnetic resonance imaging features between the two subtypes of MS thus suggests the presence of two etiologically distinct diseases in Asians.<\/jats:p>","DOI":"10.1002\/ana.410400405","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:51:59Z","timestamp":1104591119000},"page":"569-574","source":"Crossref","is-referenced-by-count":230,"title":["Western versus asian types of multiple sclerosis: Immunogenetically and clinically distinct disorders"],"prefix":"10.1002","volume":"40","author":[{"given":"Kenji","family":"Yamasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Ichi","family":"Kira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhara","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanehiro","family":"Hasuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Tobimatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1991.tb02029.x"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(91)90073-I"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/346183a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.1.279"},{"key":"e_1_2_1_5_2","first-page":"19","article-title":"HLA and Japanese MS","volume":"12","author":"Naito S","year":"1978","journal-title":"Tissue Antigens"},{"key":"e_1_2_1_6_2","first-page":"215","volume-title":"Multipel sclerosis East and WEst","author":"Naito S"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.1989.tb00496.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(90)90031-J"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1991.tb01868.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(92)90019-J"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1992.tb05135.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.9.845"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(81)90083-6"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(93)90171-T"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/ana.410130302","article-title":"New diagnostic criteria for multiple sclerosis: guidelines for research protocols","volume":"133","author":"Poser CM","year":"1983","journal-title":"J Ann Neurol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290214"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1444"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(91)90192-A"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00161-T"},{"key":"e_1_2_1_20_2","unstructured":"HasuoK MizushimaA MiharaF et al. Contrast\u2010enhanced MRI imaging in spinal arteriovenous malformations and fistulas before and after embolization theraphy.Neuroradiology1996(in press)"},{"key":"e_1_2_1_21_2","first-page":"397","volume-title":"HLA 1991: PRoceedings of the 11th International Histocompatbility Workshop and Conference","author":"Kimura A","year":"1992"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(94)90077-9"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01348.x"},{"key":"e_1_2_1_24_2","first-page":"297","volume-title":"Multiple sclerosis East and West J","author":"Ikuta F","year":"1982"},{"key":"e_1_2_1_25_2","first-page":"273","volume-title":"Multiple sclerosis East and West","author":"Tabira T","year":"1982"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.4049\/jimmunol.145.2.540","article-title":"Fine specificity and HLA restriction of myelin basic protein\u2010specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals","volume":"145","author":"Martin R","year":"1990","journal-title":"J. Immunol"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.20.7968"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90348-8"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410400405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410400405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T17:22:55Z","timestamp":1695835375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410400405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,10]]}},"alternative-id":["10.1002\/ana.410400405"],"URL":"https:\/\/doi.org\/10.1002\/ana.410400405","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,10]]}}}