{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:56:31Z","timestamp":1779893791613,"version":"3.53.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2929,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1996,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tacrolimus (FK506) has recently been approved for immunosuppressionin organ transplantation, although its use is accompanied by a wide spectrum ofneurotoxic side effects. We describe the clinical, radiological, and pathological features of 3 cases of tacrolimus\u2010related leukoencephalopathy. The syndrome of immunosuppression\u2010related leukoencephalopathy is proposed as an uncommon neurological syndrome occurring in patintw with organ transplants involving demyelination, in particular in the parieto\u2010occipital region and centrum semiovale. Although the syndrome is not associated with a particular (absolute) serum level of tacrolimus, it resolves spontaneously upon decreasing the dose. The tacrolimus\u2010related syndrome has a similar radiographic and pathologic appearance as the analogous syndrome that occurs in patients taking cyclosporine.<\/jats:p>","DOI":"10.1002\/ana.410400406","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:51:59Z","timestamp":1104591119000},"page":"575-580","source":"Crossref","is-referenced-by-count":105,"title":["Immunosuppression\u2010induced leukoencephalopathy from tacrolimus (FK506)"],"prefix":"10.1002","volume":"40","author":[{"given":"Steven L.","family":"Small","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"Bramblett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin H.","family":"Eidelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie B.","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_1_2","unstructured":"Tacrolimus (FK506) for organ transplants.Med Lett1994:82\u201383"},{"key":"e_1_2_1_2_2","first-page":"A974","article-title":"US multicenter prospective randomized trail comparing primary immunosuppressionwith FK506 vs cyclosporin (CyA) following liver transplantation","volume":"104","author":"Porayko MK","year":"1994","journal-title":"Gastroenterology"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91766-3"},{"key":"e_1_2_1_4_2","first-page":"3175","article-title":"Neurologic complications of FK506","volume":"23","author":"Eidelman BH","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199012000-00028"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350422"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2417"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92053-7"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80300-3"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710013171404"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92263-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199008093230616"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.6.1072"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.3.405"},{"key":"e_1_2_1_15_2","first-page":"651","article-title":"MR imaging of reversible cyclosporin A\u2010induced neurotoxicity","volume":"12","author":"Truwit CL","year":"1991","journal-title":"J Am J Neuroradiol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602223340803"},{"key":"e_1_2_1_17_2","first-page":"3173","article-title":"Similar clinical presentationof neurotoxicity following FK506 and cyclosporin in a liver transplant recipient","volume":"23","author":"Freise CE","year":"1991","journal-title":"Transplant Proc"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.5.1784"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(93)90206-Y"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.3.751"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410400406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410400406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T17:23:00Z","timestamp":1695835380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410400406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,10]]}},"alternative-id":["10.1002\/ana.410400406"],"URL":"https:\/\/doi.org\/10.1002\/ana.410400406","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,10]]}}}