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Most cases have antecedent infection with <jats:italic>Campylobacter jejuni<\/jats:italic> and many have antibodies directed toward GM1 ganglioside\u2010like epitopes, but the mechanism of nerve\u2010fiber injury has not been defined. In 7 fatal cases of AMAN, immunocytochemistry demonstrated the presence of IgG and the complement activation product C3d bound to the axolemma of motor fibers. The most frequently involved site was the nodal axolemma, but in more severe cases IgG and C3d were found within the periaxonal space of the myelinated internodes, bound to the outer surface of the motor axon. These results suggest that AMAN is a novel disorder caused by an antibody\u2010 and complement\u2010mediated attack on the axolemma of motor fibers.<\/jats:p>","DOI":"10.1002\/ana.410400414","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:51:59Z","timestamp":1104591119000},"page":"635-644","source":"Crossref","is-referenced-by-count":418,"title":["Acute motor axonal neuropathy: An antibody\u2010mediated attack on axolemma"],"prefix":"10.1002","volume":"40","author":[{"given":"Charlene","family":"Hafer\u2010Macko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Tsang","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony 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