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Previous animal studies indicate striatal VMAT2 density is linearly related to the integrity of substantia nigra dopamine neurons and is not subject to drug\u2010or lesion\u2010compensatory regulation. In the present studies, kinetic compartmental modeling was employed to estimate blood\u2010brain [<jats:sup>11<\/jats:sup>C]DTBZ transport (<jats:italic>K<\/jats:italic><jats:sub>1<\/jats:sub>,) and VMAT2 binding site density (tissue\u2010to\u2010plasma DTBZ distribution volume, <jats:italic>DV<\/jats:italic>)from the cerebral and plasma DTBZ time courses her intravenous tracer injection. In controls, we found reductions of putamen DTBZ <jats:italic>DV<\/jats:italic> with advancing age, corresponding to losses of 0.77% per year in specific VMAT2 binding. Parkinson's disease (PD) patients had reduction in specific DTBZ <jats:italic>DV<\/jats:italic> in the putamen (\u221261%) and in the caudate nucleus (\u221243%). There was no overlap of lowest specific putamen DTBZ <jats:italic>DV<\/jats:italic> between individual elderly controls and PD patients. The present results indicate the suitability of [<jats:sup>11<\/jats:sup>C]DTBZ PET for objective quantification of nigrostriatal integrity, including evaluation of PD progression and its possible therapeutic modification.<\/jats:p>","DOI":"10.1002\/ana.410400609","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:53:19Z","timestamp":1104591199000},"page":"873-884","source":"Crossref","is-referenced-by-count":268,"title":["Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging"],"prefix":"10.1002","volume":"40","author":[{"given":"Kirk A.","family":"Frey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Koeppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Kilbourn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry M.","family":"Vander Borght","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Albin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sid","family":"Gilman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Kuhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"925","article-title":"Dopamine (3\u2010hydroxytyramine) and brain function","volume":"18","author":"Hornykiewicz O","year":"1966","journal-title":"Pharmacol Rev"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198804073181402"},{"key":"e_1_2_1_4_2","first-page":"564","volume-title":"Autonomic failure: a textbook of clinical disorders of the autonomic nervous system","author":"Daniel SE","year":"1992"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1964.00460160003001"},{"issue":"3","key":"e_1_2_1_6_2","first-page":"17","article-title":"Do environmental toxins cause Parkinson's disease? 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