{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:34:10Z","timestamp":1791146050742,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2806,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1997,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hereditary frontotemporal dementia (HFTD) is a rare autosomal dominant form of presenile dementia characterized by behavioral changes and reduced speech. Three multigeneration kindreds with this condition, in the Netherlands, were investigated for clinicopathological comparison and linkage analysis. Frontotemporal atrophy on computed tomographic scanning and\/or magnetic resonance imaging was usually present. Single\u2010photon emission computed tomography (SPECT) showed frontal hypoperfusion in the early phase of the disease. Brain tissue showed moderate to severe atrophy of frontal and temporal cortex with neuronal loss, gliosis, and spongiosis. Pick bodies were lacking in all cases of the 3 families. The mean age of onset varied significantly between families. We report here evidence for linkage to chromosome 17q21\u2013q22 with a maximum lod score of 4.70 at \u0398 = 0.05 with the marker D17S946 and D17S791. Three other neurodenegenerative disorders with a strong clinical and pathological resemblance have recently been mapped to the same chromosomal region, suggesting that a group of clinically related neurodegenerative disorders may originate from mutations in the same gene.<\/jats:p>","DOI":"10.1002\/ana.410410205","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:58:19Z","timestamp":1104591499000},"page":"150-159","source":"Crossref","is-referenced-by-count":121,"title":["Hereditary frontotemporal dementia is linked to chromosome 17q21\u2014q22: A genetic and clinicopathological study of three dutch families"],"prefix":"10.1002","volume":"41","author":[{"given":"P.","family":"Heutink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rizzu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Kros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tibben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Niermeijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Van Duijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. A.","family":"Oostra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"Van Swieten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.4.416"},{"key":"e_1_2_1_3_2","unstructured":"SandersJ SchenkVWD van VeenP. A family with Pick's disease. Verhandelingen de Koninklijke Nederlandse Akademie van Wetenschappen1939; section 2 part 38 no. 3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1959.tb01476.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/105.3.443"},{"key":"e_1_2_1_6_2","first-page":"165","article-title":"Ueber die beziehungen der senilen Hirnatrophie zur Aphasie","volume":"17","author":"Pick A","year":"1892","journal-title":"Prag Med Wochenschr"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02866679"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1192\/bjp.78.321.302","article-title":"Pick's disease (circumscribed senile atrophy) and Alzheime's disease","volume":"78","author":"Thorpe FT","year":"1932","journal-title":"J Ment Sci"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1939.02270170142009"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1943.02290210066004"},{"key":"e_1_2_1_11_2","unstructured":"van MansveltJ.Pick's disease. A syndrome of lobar cerebral atrophy its clinic0\u2010anatomical and histopathological types. Thesis 1954; Enschede: van der Loeff"},{"key":"e_1_2_1_12_2","first-page":"193","article-title":"Frontal bobe degeneration of non\u2010Alzheimer type","volume":"6","author":"Brun A","year":"1987","journal-title":"Neurophatology"},{"key":"e_1_2_1_13_2","first-page":"233","volume-title":"Handbook of clinical neurology","author":"Tissot R","year":"1985"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.3.353"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.2.251"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.9.1374"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160407"},{"key":"e_1_2_1_18_2","first-page":"160","article-title":"Spectrum of frontal lobe dementia in a Swedish family","volume":"4","author":"Passant U","year":"1993","journal-title":"Dementia"},{"key":"e_1_2_1_19_2","first-page":"300","article-title":"Apolipoprotein E4 alleles and non\u2010Alzheimer's disease forms of dementia","volume":"2","author":"Neary D","year":"1993","journal-title":"Neurodegeneration"},{"key":"e_1_2_1_20_2","first-page":"195","article-title":"The lobar atrophies are not prion encephalopathies","volume":"2","author":"Owen F","year":"1993","journal-title":"Neurodegeneration"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.6.762"},{"key":"e_1_2_1_22_2","first-page":"1159","article-title":"Localisation of disinhibition\u2010dementia\u2010parkinsonism\u2010amyotrophy complex to 17q21\u201022","volume":"55","author":"Wilhelmsen KC","year":"1994","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.6.1062"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.1.151"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.9.1633"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320303"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.10.1878"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"e_1_2_1_29_2","first-page":"388","article-title":"Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction","volume":"44","author":"Weber JL","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/359794a0"},{"key":"e_1_2_1_31_2","unstructured":"Information available through the Whitehead Institute World Wide Web site (http:\/\/www\u2010genome.wi.mit.edu\/)"},{"key":"e_1_2_1_32_2","first-page":"460","article-title":"Easy calculations of lod scores and genetic risks on a small computer","volume":"36","author":"Lathrop GM","year":"1984","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_33_2","unstructured":"Online Mendelian Inheritance in Man. Catalogs of autosomal dominant autosomal recessive and X\u2010linked phenotypes available through World Wide Web (http:\/\/www3.ncbi.nlm.nih.gov\/Omim\/)"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.18.7260"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.19.7611"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3840915"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90205-S"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3008331"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90619-7"},{"key":"e_1_2_1_40_2","first-page":"961","article-title":"Physical linkage of Hox 2.1 and nerve growth factor receptor","volume":"51","author":"Bentley KL","year":"1989","journal-title":"Cytogenet Cell Genet"},{"key":"e_1_2_1_41_2","unstructured":"Human Genome DataBase available through World Wide Web (http:\/\/gdbwww.gdb.org\/)"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.11.4051"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02780339"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270407"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1383"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.3.339"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410410205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410410205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T06:38:12Z","timestamp":1698475092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410410205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["10.1002\/ana.410410205"],"URL":"https:\/\/doi.org\/10.1002\/ana.410410205","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}