{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:41:39Z","timestamp":1781214099322,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2747,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A subset of human immunodeficiency virus (HIV)\u2010infected patients develop persistent CD8 hyperlymphocytosis and a Sj\u00f6gren's syndrome\u2010like syndrome associated with multivisceral CD8 T\u2010cell infiltration, known as the diffuse infiltrative lymphocytosis syndrome (DILS). Patients with DILS tend to have higher CD4 cell counts, fewer opportunistic infections, and longer survival times than other HIV\u2010infected patients. Peripheral nerve involvement in DILS has been poorly documented. We studied 12 HIV\u2010infected patients with CD8 hyperlymphocytosis, DILS, and clinical signs of peripheral neuropathy. Two of 4 patients who were HLA typed were HLA\u2010DR5 and 1 was HLA\u2010DR6. All patients had the sicca syndrome and multivisceral involvement. The neuropathy was acute or subacute, always painful, and symmetrical in 8 cases. Electrophysiology was consistent with axonal neuropathy in 10 of 12 patients. Nerve biopsy showed marked angiocentric CD8 infiltrates without mural necrosis (12 of 12), and abundant expression of HIV p24 protein in macrophages (12 of 12). The HIV genome was detected by polymerase chain reaction in nerve homogenates. Zidovudine therapy was associated with improvement in 6 of 6 patients and steroid therapy was beneficial in 4 of 5 patients. No T\u2010cell lymphoma was observed during follow\u2010up, but 2 patients developed a primary B\u2010cell lymphoma. We conclude that DILS neuropathy represents HIV\u2010associated neuropathy, characterized by marked CD8 infiltration and abundant HIV in nerve, that improves with zidovudine or steroid therapy, and probably reflects a systemic host\u2010determined and antigendriven response to HIV.<\/jats:p>","DOI":"10.1002\/ana.410410406","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:58:49Z","timestamp":1104591529000},"page":"438-445","source":"Crossref","is-referenced-by-count":79,"title":["Peripheral neuropathy in human immunodeficiency virus\u2014infected patients with the diffuse infiltrative lymphocytosis 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