{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T20:24:53Z","timestamp":1775593493813,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2717,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1997,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the relationship between APOE genotype and rate of disease progression and survival in 99 patients with probable Alzheimer's disease (AD) who were followed biannually for up to 6 years. Patients were stratified into two groups, those with and without at least one APOE \u03f54 allele. The rate of decline in modified Mini\u2010Mental State Examination scores was slower, the presence of extrapyramidal signs was decreased, and the development of myoclonus occurred later among patients with APOE \u03f54 alleles compared with patients with other genotypes. Compared with patients with other genotypes. Compared with patients without an APOE \u03f54 allele, the risk of mortality was also decreased in patients with at least one \u03f54 allele (<jats:italic>RR<\/jats:italic> = 0.38; CI = 0.17\u22120.84, <jats:italic>P<\/jats:italic> &lt; 0.02). Because the decline in mental ability as well as the development of myoclonus and extrapyramidal signs are consistent manifestations of disease progression, our results imply that APOE \u03f54 is associated with a less aggressive form of AD.<\/jats:p>","DOI":"10.1002\/ana.410410510","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T09:59:32Z","timestamp":1104573572000},"page":"615-620","source":"Crossref","is-referenced-by-count":92,"title":["The absence of an apolipoprotein \u03f54 allele is associated with a more aggressive form of Alzheimer's disease"],"prefix":"10.1002","volume":"41","author":[{"given":"Yaakov","family":"Stern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Albert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane M.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Bell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Marder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Sano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Albert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caridad Del\u2010Castillo","family":"Castenada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Bylsma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Tycko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Mayeux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370510"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370509"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.7.1323"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199307010-00002"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.6.645"},{"issue":"1","key":"e_1_2_1_8_2","first-page":"179","article-title":"Modified mini\u2010mental state examination: validity and reliability","volume":"37","author":"Stern Y","year":"1987","journal-title":"Neurology"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1975.00490510088009"},{"key":"e_1_2_1_11_2","first-page":"3","volume-title":"The comprehensive management of Parkinson's disease","author":"Stern MB","year":"1978"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530230055021"},{"key":"e_1_2_1_13_2","volume-title":"Wechsler adult intelligence scale\u2010revised","author":"Wechsler D","year":"1981"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.4.479"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-2275(20)43176-1","article-title":"Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhAI","volume":"31","author":"Hixson J","year":"1991","journal-title":"J Lipid Res"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370217"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1467"},{"key":"e_1_2_1_18_2","volume-title":"Applied regression analysis","author":"Draper N","year":"1981"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19960530)15:10<1023::AID-SIM212>3.0.CO;2-7"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6963.1202"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530230049020"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199603000-00007"},{"key":"e_1_2_1_23_2","first-page":"132","article-title":"Predictors of mortality in Alzheimer's disease","volume":"26","author":"Stern Y","year":"1989","journal-title":"Ann Neurol"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/089198879500800302"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.10.1649"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-46776-9_3"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.9.1689"},{"key":"e_1_2_1_28_2","first-page":"1","article-title":"Utility of extrapyramidal signs and psychosis as predictors of cognitive and functional decline, nursing home admission and death in Alzheimer's disease: prospective analyses from the predictors study","volume":"45","author":"Stern Y","year":"1995","journal-title":"Neurology"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2184"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330307"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(95)00031-3"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540260050015"},{"key":"e_1_2_1_33_2","first-page":"269","article-title":"Progression of Alzheimer's disease over four years in patients with silent stroke","volume":"36","author":"Marder K","year":"1994","journal-title":"Ann Neurol"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410410510","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410410510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T07:25:26Z","timestamp":1698477926000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410410510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,5]]}},"alternative-id":["10.1002\/ana.410410510"],"URL":"https:\/\/doi.org\/10.1002\/ana.410410510","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5]]}}}