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First, 66 patients with probable Alzheimer's disease with a spectrum of dementia severity (Mini\u2010Mental State Examination score, 0\u201323) were recruited and studied. Cortical metabolic activity was analyzed topographically using three\u2010dimensional stereotactic surface projections. Regression analysis was performed for each brain pixel to predict metabolic patterns of very early disease. Predictions were tested prospectively in a group of 8 patients who complained only of memory impairment without general cognitive decline (Mini\u2010Mental State Examination score, 25 \u00b7 1) at the time of scanning but whose condition later progressed to probable Alzheimer's disease. Both results were compared to cerebral metabolic activity in 22 age\u2010similar normal control subjects. Prediction and analysis of actual patients consistently indicated marked metabolic reduction (21\u201322%) in the posterior cingulate cortex and cinguloparietal transitional area in patients with very early Alzheimer's disease. Mean metabolic reduction in the posterior cingulate cortex was significantly greater than that in the lateral neocortices or parahippocampal cortex. The result suggests a functional importance for the posterior cingulate cortex in impairment of learning and memory, which is a feature of very early Alzheimer's disease.<\/jats:p>","DOI":"10.1002\/ana.410420114","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:02:27Z","timestamp":1104591747000},"page":"85-94","source":"Crossref","is-referenced-by-count":1434,"title":["Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease"],"prefix":"10.1002","volume":"42","author":[{"given":"Saroshi","family":"Minoshima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Giordani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Berent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk 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