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These include the L\u2010type voltage\u2010gated calcium channel of skeletal muscle (hypokalemic periodic paralysis), the neuronal P\/Q\u2010type voltage\u2010gated calcium channel (familial hemiplegic migraine, episodic ataxia type 2, spinocerebellar ataxia 6, and Lambert\u2013Eaton myasthenic syndrome), and the skeletal muscle ryanodine receptor (malignant hyperthermia and central core disease). The discovery of these and other calcium channelopathies should help to clarify how different mutations affect shannel function and how altered channel function produces disease, and may lead to new treatments for these conditions.<\/jats:p>","DOI":"10.1002\/ana.410420302","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:04:16Z","timestamp":1104591856000},"page":"275-282","source":"Crossref","is-referenced-by-count":68,"title":["Calcium channels in neurological disease"],"prefix":"10.1002","volume":"42","author":[{"given":"David A.","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"The release of neural transmitter substances","author":"Katz B.","year":"1969"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210402"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)80030-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.45.27975"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.63.070194.004135"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.35.040195.003423"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(96)01021-8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2165278"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/355827a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1357749"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7832825"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"13765","DOI":"10.1016\/S0021-9258(19)85166-9","article-title":"The ryanodine receptor\/Ca2+ release channel","volume":"268","author":"McPherson PS","year":"1993","journal-title":"J Biol Chem"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/382719a0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(94)90074-4"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)89080-X"},{"key":"e_1_2_1_17_2","unstructured":"Online Mendelian Inheritance in Man OMIM (TM). 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