{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:33:47Z","timestamp":1793111627758,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2594,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mutations in copper\/zinc superoxide dismutase (SOD1) cause a subset of cases of autosomal dominant familial amyotrophic lateral sclerosis (FALS). Transgenic mice that express these point mutations develop progressive paralysis and motor neuron loss thought to be caused by a gain\u2010of\u2010function of the enzyme. The gain\u2010of\u2010function may be an enhanced ability of the mutant SOD1 to generate \u00b7OH radicals or to facilitate peroxynitrite\u2010mediated nitration of proteins. We found significant increases in concentrations of 3\u2010nitrotyrosine, a marker of peroxynitrite\u2010mediated nitration, in upper and lower spinal cord and in cerebral cortex of transgenic mice with the FALS\u2010associated G93A mutation. Malondialdehyde, a marker of lipid peroxidation, was increased in cerebral cortex. 3\u2010Nitrotyrosine\u2010, heme oxygenase\u20101\u2013, and malondialdehyde\u2010modified protein immunoreactivities were increased throughout SOD1 transgenic mice spinal cord but particularly within motor neurons. These results suggest that the gain\u2010of\u2010function of at least one mutant SOD1 associated with FALS involves increased protein nitration and oxidative damage, which may play a role in neuronal degeneration.<\/jats:p>","DOI":"10.1002\/ana.410420309","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:04:16Z","timestamp":1104591856000},"page":"326-334","source":"Crossref","is-referenced-by-count":208,"title":["Increased 3\u2010nitrotyrosine and oxidative damage in mice with a human copper\/zinc superoxide dismutase mutation"],"prefix":"10.1002","volume":"42","author":[{"given":"Robert J.","family":"Ferrante","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Shinobu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg B.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell T.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig E.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil W.","family":"Kowall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Gurney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Flint","family":"Beal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.1994.0002"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/362059a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64052366.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0596-43"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90346-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8209258"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.3.689"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90259-7"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8351519"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.22.12240"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5248.515"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.12.5709"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/364584a0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90432-V"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90431-U"},{"key":"e_1_2_1_17_2","first-page":"1271","article-title":"Development of central nervous system pathology in a murine transgenic model of human amyotrophic lateral sclerosis","volume":"145","author":"Dal Canto MC","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00063-V"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb03143.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-12-08419.1995"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(94)33035-2"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1993.1006"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.7.3155"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.4.1620"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)80391-9"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64020936.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(90)90206-Q"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/57.5.715S"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390203"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(94)00273-H"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)12042-3"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.4.1177"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.8.3377"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90263-1"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/3.10.1757"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)00224-8"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/375061a0"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.2.535"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)12039-7"},{"key":"e_1_2_1_40_2","first-page":"1943","article-title":"3\u2010Nitrotyrosine in ALS","volume":"22","author":"Beal MF","year":"1996","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-0618(96)00137-8"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(96)00090-1"},{"key":"e_1_2_1_43_2","first-page":"2142","article-title":"Carboxybuckminsterfullerene: novel antioxidants with neuroprotective efficacy in vitro and in a mouse model of ALS","volume":"22","author":"Dugan LL","year":"1996","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_44_2","first-page":"2142","article-title":"Is neuronal nitric oxide synthase involved in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis","volume":"22","author":"Sasaki M","year":"1996","journal-title":"Soc Neurosci Abstr"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410420309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410420309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T03:19:54Z","timestamp":1698463194000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410420309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1002\/ana.410420309"],"URL":"https:\/\/doi.org\/10.1002\/ana.410420309","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}