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In a similar manner, the multitude of phenomenological descriptions of the effects of exogenous melatonin is contrasted by the limited understanding of the underlying mechanisms and the lack of firmly established clinical applications for the hormone. Future randomized, double\u2010blind, placebo\u2010controlled clinical studies wil be necessary to determine the precise indications, treatment regimens, and safety of melatonin in clinical practice. The recent rapid progress in the area of melatonin research should lead to a better understanding of its role in human health and disease.<\/jats:p>","DOI":"10.1002\/ana.410420404","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:04:20Z","timestamp":1104591860000},"page":"545-553","source":"Crossref","is-referenced-by-count":45,"title":["Melatonin: A clinical perspective"],"prefix":"10.1002","volume":"42","author":[{"given":"Palmen D.","family":"Penev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis C.","family":"Zee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Melatonin and the mammalian pineal gland","author":"Arendt J.","year":"1995"},{"key":"e_1_2_1_3_2","first-page":"3","article-title":"Pineal research: the decade of 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