{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:38:17Z","timestamp":1791225497063,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2503,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To clarify the role of the cerebellum in pursuit initiation (first 100 msec), we used infrared oculography to examine the effect of unilateral cerebellar lessions on the initial (0\u201320 msec) and later (80\u2013100 msec) periods as well as the steady\u2010state response (200\u2013300 msec) of horizontal smooth pursuit in 10 patients with unilateral cerebellar lesions. These results were compared with those of 17 age\u2010matched healthy subjects. Smooth pursuit was elicited with a step\u2010ramp target movement with randomized horizontal directions and velocities of 10\/sec and 30\/sec. In the first 20\u2010msec pursuit, velocity was 22% lower toward the side of the cerebellar lesion than away from it and 16% lower in the period 80 to 100 msec (normal differences, 2% and 3%). Later (200\u2013300 msec), the ipsiversive\/contraversive difference was smaller, but pursuit velocity in both directions was significantly lower in patients than in normals. No lesion affected the floccular region and\/or the nodulus\/uvula. Five lesions extended so far medially that they could have affected the medial deep cerebellar nucleus (fastigial nucleus). The remaining five were in the lateral hemisphere in areas previously considered uninvolved in pursuit generation. Our findings prove that the cerebellum participates in human pursuit initiation and that lesions in the lateral cerebellum possibly affect smooth pur\u00f6it.<\/jats:p>","DOI":"10.1002\/ana.410420611","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:10:08Z","timestamp":1104592208000},"page":"891-898","source":"Crossref","is-referenced-by-count":57,"title":["Unilateral cerebellar lesions affect initiation of ipsilateral smooth pursuit eye movements in humans"],"prefix":"10.1002","volume":"42","author":[{"given":"A.","family":"Straube","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Scheuerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Eggert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1152\/jn.1987.57.5.1446","article-title":"Human smooth pursuit: stimulus\u2010dependent responses","volume":"57","author":"Carl JR","year":"1987","journal-title":"J Neurophysiol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-06-01662.1985"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1986.56.4.953"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.1.150"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.2.160"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868394"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.58.1.91"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/99.2.207"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1981.46.4.878"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1978.41.3.733"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.63.5.1241"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.6.2714"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1979.00500410059008"},{"key":"e_1_2_1_15_2","first-page":"618","article-title":"Oculomotor defects in cerebellectomized monkeys","volume":"12","author":"Westheimer G","year":"1973","journal-title":"Invest Opthalmol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.59.10.560"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1961.sp006811"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(93)90158-S"},{"key":"e_1_2_1_19_2","first-page":"856","article-title":"Smooth pursuit deficits after muscimol inactivation of the caudal fastigial nucleus in macaque","volume":"20","author":"Robinson FR","year":"1994","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_20_2","unstructured":"RobinsonFR StraubeA FuchsAF. 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