{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T02:38:23Z","timestamp":1778294303089,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2441,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1998,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prompted by the findings of previous studies with positron emission tomography and single photon emission computed tomography, which demonstrated hypoperfusion or hyperperfusion in the left temporal lobe in isolated patients with transient global amnesia (TGA), we compared the sensitivity of diffusion\u2010weighted (DW) magnetic resonance imaging (MRI) with that of conventional T1\u2010 and T2\u2010weighted MRI in patients with TGA. Ten patients with the typical syndrome of a pure TGA were included in the study. For all patients, a coronal DW sequence, a steady\u2010state free precession (SSFP) sequence, and conventional T1\u2010 and T2\u2010weighted turbo spin\u2010echo sequences were obtained. Seven of the 10 patients had elevated signal intensity in the left hippocampal region on DW MRI; moreover, 3 of these 7 patients exhibited bilateral signal abnormality in this sequence. All conventional T1\u2010 and T2\u2010 weighted images as well as all follow\u2010up studies were normal. The signal elevation in DW MRI correlates with a decrease in the interstitial space and with cellular edema in the temporal lobe during TGA. The underlying pathomechanism causing this cellular edema cannot be clearly outlined using DW MRI. Our data are, however, compatible with spreading depression. This is the first study to show that DW MRI is a sensitive MRI method for evaluating TGA, especially in the early stage of the disease.<\/jats:p>","DOI":"10.1002\/ana.410430206","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:12:24Z","timestamp":1104592344000},"page":"164-170","source":"Crossref","is-referenced-by-count":113,"title":["Diffusion\u2010weighted MRI in transient global amnesia: Elevated signal intensity in the left mesial temporal lobe in 7 of 10 patients"],"prefix":"10.1002","volume":"43","author":[{"given":"Michael","family":"Strupp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Br\u00fcning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren Hua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Deimling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Reiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"212","article-title":"Syndrome of isolated episodes of confusion with amnesia","volume":"5","author":"Bender MB","year":"1956","journal-title":"J Hillside Hospital"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.3.639"},{"key":"e_1_2_1_4_2","volume-title":"Transient amnesia. clinical and neuropsychological aspects","author":"Hodges JR","year":"1991"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070313"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1992.00530290131022"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199301000-00011"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.53.4.339"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.11.1227"},{"key":"e_1_2_1_10_2","first-page":"591","article-title":"Diffusion MR imaging. clinical application","volume":"159","author":"Le Bihan D","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.2.3393671"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.161.2.3763909"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910180106"},{"key":"e_1_2_1_14_2","first-page":"1097","article-title":"MR diffusion imaging of cerebral infarctions in humans","volume":"13","author":"Chien D","year":"1992","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410505"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1695690"},{"key":"e_1_2_1_17_2","unstructured":"DeimlingM HeidO. 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