{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:51:16Z","timestamp":1790970676599,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2441,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1998,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aggregated \u03c4 proteins constitute the basic matrix of neuronal inclusions specific to numerous neurodegenerative disorders. Monodimensional and two\u2010dimensional Western blot analyses performed on cortical brain homogenates allowed discrimination between disease\u2010specific \u03c4 protein profiles. These observations raised the issue of the physiopathological significance of such specificities. Alzheimer's disease (AD) pathological \u03c4 proteins (PTPs) (\u03c4 74, 69, 55) were compared with those of Pick's disease (PiD) (\u03c4 64, 55) using a panel of antibodies against peptidic sequences of \u03c4 isoforms corresponding to exons 2, 3, and 10. AD and PiD could then be critically differentiated by the absence of translated \u03c4 isoforms with exon 10 in PiD PTPs, along with the absence of the phosporylation site on Ser262. Immunohistochemical studies corroborate these findings. Indeed, Pick bodies were strongly immunostained by an anti\u2010\u201cexon 2\u201d antibody but failed to reveal any anti\u2010exon 10 reactive epitope. Tangles in AD contained exon 2, 3, and 10 epitopes. Altogether, our results demonstrated that Pick bodies develop within specific neuronal subsets that express specific patterns of \u03c4 isoforms lacking exon 10 peptidic sequence. We conclude that neurodegenerative disorders imply attrition of selectively vulnerable neuronal subsets, a process revealed, and may be sustained by specific \u03c4 isoform patterns.<\/jats:p>","DOI":"10.1002\/ana.410430209","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:12:24Z","timestamp":1104592344000},"page":"193-204","source":"Crossref","is-referenced-by-count":192,"title":["Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their \u03c4 isoform distribution and phosphorylation"],"prefix":"10.1002","volume":"43","author":[{"given":"A.","family":"Delacourte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sergeant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wattez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Gauvreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Robitaille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)62588-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/1.1.103"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540250089017"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(95)00021-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427214"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294457"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199605000-00006"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293314"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199601000-00006"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050436"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296179"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308912"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1899488"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90117-V"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296367"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/BF00293317","article-title":"Biochemical mapping of neurofibrillary degeneration in a case of progressive supranuclear palsy: evidence for general cortical involvement","volume":"87","author":"Vermersch P","year":"1994","journal-title":"Acta Neuropathol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199602000-00004"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.3.711"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00304633"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(95)00195-6"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(89)90131-7"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308927"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.2.503"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01473-X"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3029875"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.18.8463"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0796-783"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.65041658.x"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.69020834.x"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)41496-8"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(96)00003-4"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11484-E"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3010871"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.32.18917"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90264-X"},{"key":"e_1_2_1_38_2","first-page":"159","article-title":"Molecular neuropathology of Alzheimer's disease: in situ hybridization studies. 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