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In the lesioned striatum, the binding ratio measured by the DA presynaptic marker was reduced to 15% to 35% of the intact side (or unoperated control). After grafting with non\u2010DA cells (from dorsal mesencephalon), the DA binding ratio remained reduced to levels observed before transplantation and rats showed no behavioral recovery. In contrast, after DA neuronal transplantation, behavioral recovery occurred only after the <jats:sup>11<\/jats:sup>C\u2010CFT binding ratio had increased to 75% to 85% of the intact side. This study provides direct in vivo evidence for the dopaminergic molecular basis of functional recovery in the lesioned nigrostriatal system after neural transplantation.<\/jats:p>","DOI":"10.1002\/ana.410430318","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:15:16Z","timestamp":1104592516000},"page":"387-390","source":"Crossref","is-referenced-by-count":54,"title":["In vivo PET Imaging in rat of dopamine terminals reveals functional neural transplants"],"prefix":"10.1002","volume":"43","author":[{"given":"Anna\u2010Liisa","family":"Brownell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Livni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Galpern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Isacson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350208"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211263272201"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380307"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504273321702"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211263272202"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)80038-5"},{"key":"e_1_2_1_8_2","first-page":"1","volume-title":"Neural transplantation: a practical approach","author":"Bjorklund A","year":"1992"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199203000-00013"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1069"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340331"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890090107"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02444003"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199510010-00016"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1004"},{"key":"e_1_2_1_16_2","first-page":"13","volume-title":"The metabolism of the human brain studied with positron emission tomography","author":"Brownell GL","year":"1985"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.0109"},{"key":"e_1_2_1_18_2","first-page":"1186","article-title":"Cocaine congeners as PET imaging probes for dopamine terminals","volume":"37","author":"Brownell A\u2010L","year":"1996","journal-title":"J Nucl Med"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350328"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410430318","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410430318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T21:08:31Z","timestamp":1698527311000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410430318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["10.1002\/ana.410430318"],"URL":"https:\/\/doi.org\/10.1002\/ana.410430318","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}