{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:53:32Z","timestamp":1791172412629,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2382,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatment of Parkinson's disease with L\u2010dopa therapy leads to long\u2010term complications, including loss of drug efficacy and the onset of dyskinesia. Adenosine A<jats:sub>2A<\/jats:sub> receptors in striatum are selectively localized to GABAergic output neurons of the striato\u2010pallidal pathway and may avoid such problems. The novel adenosine A<jats:sub>2A<\/jats:sub> receptor antagonist KW\u20106002 has been examined for antiparkinsonian activity in MPTP\u2010treated primates. Oral administration of KW\u20106002 reversed motor disability in MPTP\u2010treated common marmosets in a dose\u2010dependent manner. However, KW\u20106002 only modestly increased overall locomotor activity and did not cause abnormal movement, such as stereotypy. The ability of KW\u20106002 to reverse motor disability was maintained on repeated daily administration for 21 days, and no tolerance was observed. KW\u20106002 induced little or no dyskinesia in MPTP\u2010treated primates previously primed to exhibit dyskinesia by prior exposure to L\u2010dopa. These results suggest that selective adenosine A<jats:sub>2A<\/jats:sub> receptor antagonists represent a new class of antiparkinsonian agents that improve disability without producing hyperactivity and without inducing dyskinesia.<\/jats:p>","DOI":"10.1002\/ana.410430415","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:15:23Z","timestamp":1104592523000},"page":"507-513","source":"Crossref","is-referenced-by-count":308,"title":["Adenosine A<sub>2A<\/sub> Antagonist: A novel antiparkinsonian agent that does not provoke dyskinesia in Parkinsonian monkeys"],"prefix":"10.1002","volume":"43","author":[{"given":"Tomoyuki","family":"Kanda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald K. B.","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Kuwana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.2.340"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870020201"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(97)01096-1"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00734999"},{"key":"e_1_2_1_6_2","first-page":"331","article-title":"Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes","volume":"29","author":"Bruns RF","year":"1986","journal-title":"Mol Pharmacol"},{"key":"e_1_2_1_7_2","first-page":"143","article-title":"Nomenclature and classification of purinoceptor","volume":"46","author":"Fredholm BB","year":"1994","journal-title":"Pharmacol Rev"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90571-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90391-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb08257.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90387-9"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90551-7"},{"key":"e_1_2_1_13_2","first-page":"48","article-title":"Action of caffeine and theophylline on supersensitive dopamine receptors considerable enhancement of receptor response to treatment with DOPA and dopamine receptor agonists","volume":"52","author":"Fuxe K","year":"1974","journal-title":"Med Biol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244078"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(91)90403-O"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244956"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00090a027"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(94)90159-7"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(97)00440-X"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245479"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100606"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330515"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00229-J"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90038-P"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb16171.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-02-00605.1996"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66051882.x"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250521"},{"key":"e_1_2_1_29_2","first-page":"275","article-title":"Differential effect of selective D\u20101 and D\u20102 dopamine receptor agonists on levodopa\u2010induced dyskinesia in 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine\u2010exposed monkeys","volume":"267","author":"Blanchet P","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870110117"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.1995.tb00518.x"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(95)98374-8"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1994.tb03840.x"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410430415","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410430415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T19:48:51Z","timestamp":1698522531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410430415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["10.1002\/ana.410430415"],"URL":"https:\/\/doi.org\/10.1002\/ana.410430415","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4]]}}}