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We found that NT\u20104 protein and mRNA were present in both type I and type II fibers but were up\u2010regulated in RRFs of patients with mitochondrial encephalomyopathies; it is noteworthy that NT\u20104 was not up\u2010regulated in muscle fibers from healthy aerobically trained athletes. Thus, NT\u20104 might represent a member of a new class of candidate molecules involved in the compensatory adjustments of muscle fibers to oxidative dysfunction, and may even play a role as a signaling molecule for mitochondrial proliferation.<\/jats:p>","DOI":"10.1002\/ana.410430421","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:15:23Z","timestamp":1104592523000},"page":"536-540","source":"Crossref","is-referenced-by-count":16,"title":["Neurotrophin\u20104 is up\u2010regulated in ragged\u2010red fibers associated with pathogenic mitochondrial DNA mutations"],"prefix":"10.1002","volume":"43","author":[{"given":"Ulrich A.","family":"Walker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.","family":"Schon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022685929755"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01812848"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350407"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(96)64045-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/363266a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.8.3304"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7770776"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490420104"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.7.3060"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90209-V"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116913"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1970.00480280083010"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/33.5.2580882"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/367368a0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(94)90077-9"},{"key":"e_1_2_1_17_2","first-page":"309","article-title":"Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. 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