{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:09:07Z","timestamp":1762351747891},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2352,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to assess neurological, neuropsychological, and neuroradiological findings in long\u2010term survivors of allogeneic bone marrow transplantation (BMT) who were recruited from a hematological outpatient clinic. In addition, risk factors for the development of late neurological complications were identified. In contrast to previous studies on autopsied patients, our study design provoked a bias away from increased neurological sequelae, because patients with early complications after BMT were excluded. Fifty\u2010nine allogeneic patients and 7 autologous BMT patients underwent clinical examination, short neuropsychological testing, and cranial magnetic resonance imaging (MRI) 34 \u00b1 26 months after BMT. The pathological results of the neurological examination (abnormal 64%) and the MRI examination (white matter lesions, 54%; atrophy, 11%) were associated with the occurrence of chronic graft\u2010versus\u2010host disease (GvHD) evolving from acute GvHD, with corticosteroid therapy and with cyclosporine medication. Neuropsychological impairment (cognitive deficits, 37%) was associated with long\u2010term cyclosporine medication and age. No influence of pre\u2010BMT disease, BMT donor status, or the conditioning regimen was found. These results suggest that the frequent neurological abnormalities in long\u2010term survivors of allogeneic BMT are associated with chronic GvHD and with the resulting immunosuppression as major risk factors.<\/jats:p>","DOI":"10.1002\/ana.410430511","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:15:36Z","timestamp":1104592536000},"page":"627-633","source":"Crossref","is-referenced-by-count":68,"title":["Neurological and neuroradiological findings in long\u2010term survivors of allogeneic bone marrow transplantation"],"prefix":"10.1002","volume":"43","author":[{"given":"Claudio S.","family":"Padovan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek A.","family":"Yousry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schleuning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Holler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Jochem","family":"Kolb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Straube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-6-505"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-3-199702010-00002"},{"key":"e_1_2_1_4_2","first-page":"13","article-title":"Results of allogeneic bone marrow transplantation with unrelated or mismatched donors","volume":"19","author":"Beatty PG","year":"1992","journal-title":"Semin Oncol"},{"key":"e_1_2_1_5_2","first-page":"3","article-title":"Bone marrow transplantation: past experiences and future prospects","volume":"19","author":"Thomas ED","year":"1992","journal-title":"Semin Oncol"},{"key":"e_1_2_1_6_2","first-page":"7","article-title":"The role of autologous bone marrow transplantation in the treatment of solid tumors","volume":"19","author":"Herzig RH","year":"1992","journal-title":"Semin Oncol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30876-4"},{"key":"e_1_2_1_8_2","first-page":"393","article-title":"Neurologic complications in allogeneic bone marrow transplant patients receiving cyclosporine","volume":"8","author":"Reece DE","year":"1991","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360503"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.3.300"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.4.681"},{"key":"e_1_2_1_12_2","first-page":"1135","article-title":"Neurologic complications after allogeneic bone marrow transplantation","volume":"18","author":"Gallardo D","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.4.1004"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.7.2018.2018"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700014811"},{"key":"e_1_2_1_16_2","first-page":"959","article-title":"Comparison of SE, FSE, fast\u2010FLAIR and TGSE sequences in the detection of multiple sclerosis lesions","volume":"18","author":"Yousry TA","year":"1997","journal-title":"AJNR"},{"key":"e_1_2_1_17_2","first-page":"268","volume-title":"Practical statistics for medical research","author":"Altmann DG","year":"1991"},{"key":"e_1_2_1_18_2","volume-title":"STATISTICA for Windows (computer program manual)","year":"1996"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90010-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160507"},{"key":"e_1_2_1_21_2","first-page":"221","article-title":"Neurologische Komplikationen nach Knochenmarkstransplantation","volume":"62","author":"Diener HC","year":"1991","journal-title":"Nervenarzt"},{"key":"e_1_2_1_22_2","first-page":"2288","article-title":"Neuropsychologic impairment in adult bone marrow transplant candidates","volume":"70","author":"Andrykowski MA","year":"1992","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.4.820"},{"key":"e_1_2_1_24_2","first-page":"269","article-title":"Cognitive dysfunction in adult survivors of allogeneic marrow transplantation: relationship to dose of total body irradiation","volume":"6","author":"Andrykowski MA","year":"1990","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540340067014"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.8.1462"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199409000-00003"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.4.626"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050225"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90140-C"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199609000-00006"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30259-7"},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1182\/blood.V67.1.195.195","article-title":"The risks of central nervous system relapse and leukoencephalopathy in patients receiving marrow","volume":"67","author":"Thompson CB","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02021528"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.11.1962"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30877-6"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.7.2082"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3278379"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199309000-00004"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/89.4.543"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410430511","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410430511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T21:16:23Z","timestamp":1698527783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410430511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1002\/ana.410430511"],"URL":"https:\/\/doi.org\/10.1002\/ana.410430511","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}