{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T10:35:52Z","timestamp":1751020552978},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2352,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of the anti\u2013voltage\u2010gated Ca<jats:sup>2+<\/jats:sup> channel (VGCC) antibody obtained from patients with Lambert\u2010Eaton myasthenic syndrome (LEMS) on autonomic neurotransmission were studied in in\u2010vitro experiments. The releases of acetylcholine (ACh) and norepinephrine from the autonomic nerves were evaluated by changes in the contractile responses of guinea pig taenia caeci and left atria to electric field stimulation, respectively. Incubations for 6 hours with LEMS serum and IgG, both of which contain anti\u2010VGCC antibody, markedly suppressed the parasympathetic response but did not affect the sympathetic response. Pharmacological experiments with specific blockers to the VGCC subtypes showed that the Q\u2010type VGCC is closely linked to the genesis of the parasympathetic responses. We suggest that the anti\u2010VGCC antibody from the LEMS patients specifically reduces the ACh release from the parasympathetic nerve by binding to the Q\u2010type VGCC.<\/jats:p>","DOI":"10.1002\/ana.410430520","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:15:36Z","timestamp":1104592536000},"page":"677-680","source":"Crossref","is-referenced-by-count":14,"title":["Functional evaluation of inhibition of autonomic transmitter release by autoantibody from lambert eaton myasthenic syndrome"],"prefix":"10.1002","volume":"43","author":[{"given":"Hideki","family":"Houzen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morio","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakatsu","family":"Motomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youko","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsufumi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(85)90046-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(88)90037-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1990.61"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.5.720"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.3.436"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020865"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb02733.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880111105"},{"key":"e_1_2_1_10_2","first-page":"248","article-title":"Differential blockade of voltage\u2010sensitive calcium channels at the mouse neuromuscular junction by novel \u03c9\u2010conopeptides and \u03c9\u2010agatoxin\u2010IVA","volume":"273","author":"Bowersox SS","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01370157"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1391"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb16375.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-13-04155.1996"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.58.1.85"},{"key":"e_1_2_1_16_2","volume-title":"Immunochemistry in Practice","author":"Johnstone A","year":"1982"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13761.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7832825"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410430520","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410430520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T21:17:10Z","timestamp":1698527830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410430520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1002\/ana.410430520"],"URL":"https:\/\/doi.org\/10.1002\/ana.410430520","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}