{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:49:42Z","timestamp":1782816582970,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2321,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The polymorphism at codon 219 of the prion protein gene (PRNP) was found in the general Japanese population with 6% allele frequency. Herein, we examined 85 cases of sporadic Creutzfeldt\u2010Jakob disease (CJD) for the codon 219 polymorphism. The codon 219<jats:sup>Glu\/Lys<\/jats:sup> heterozygous polymorphism was not found in these CJD cases. In addition, we examined 43 patients with dementia of non\u2010CJD origin, and 4 were found to have the codon 219 <jats:sup>Glu\/Lys<\/jats:sup> heterozygous polymorphism with a similar allele frequency as in the general population. Thus, the codon 219<jats:sup>Glu\/Lys<\/jats:sup> heterozygous polymorphism might be uniquely excluded from sporadic CJD.<\/jats:p>","DOI":"10.1002\/ana.410430618","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:16:22Z","timestamp":1104592582000},"page":"826-828","source":"Crossref","is-referenced-by-count":129,"title":["Codon 219 lys allele of PRNP is not found in sporadic Creutzfeldt\u2010Jakob disease"],"prefix":"10.1002","volume":"43","author":[{"given":"Satoshi","family":"Shibuya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryong\u2010Woon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June","family":"Tateishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuyuki","family":"Kitamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6801762"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90207-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1994.0034"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/338342a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92317-6"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700010965"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390613"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1439789"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/353801b0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/352340a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(95)00034-P"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1995.tb00625.x"},{"key":"e_1_2_1_14_2","first-page":"888","article-title":"Codon 219 polymorphism of PRNP in healthy caucasians and Creutzfeldt\u2010Jakob disease patients","volume":"58","author":"Petraroli R","year":"1996","journal-title":"Am J Hum Genet."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.62.5.454"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.19.10069"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410430618","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410430618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T16:48:52Z","timestamp":1698511732000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410430618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,6]]}},"alternative-id":["10.1002\/ana.410430618"],"URL":"https:\/\/doi.org\/10.1002\/ana.410430618","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,6]]}}}