{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:28:19Z","timestamp":1791890899575,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2260,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1998,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A common pattern of hypoxic\u2013ischemic cerebral injury in the term newborn involves predominantly cerebral cortex and subcortical white matter. We describe 20 term newborns with moderate or severe acute hypoxic\u2013ischemic encephalopathy who exhibit a different pattern of abnormalities on computed tomography, with evidence of decreased tissue attenuation predominantly in thalami and basal ganglia and relative preservation of cerebral cortex and white matter. Profound, acute hypoxic\u2013ischemic insult (eg, umbilical cord prolapse, uterine rupture, or massive placental abruption) was documented in 16 of 20 infants (80%). Characteristic clinical features during the newborn period included irritability, tonic posturing of limbs, and persistent lower cranial nerve dysfunction, often with prominent tongue fasciculations. This pattern of central injury appears to be highly predictive of poor outcome; 7 newborns (35%) died, and all survivors who had follow\u2013up to 18 months of age (11) had major neurological sequelae (eg, spastic quadriplegia, choreoathetosis, and persistent feeding problems). This pattern of hypoxic\u2013ischemic cerebral injury corresponds closely to experimental animal models of \u201cacute total\u201d perinatal asphyxia.<\/jats:p>","DOI":"10.1002\/ana.410440205","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:21:18Z","timestamp":1104592878000},"page":"161-166","source":"Crossref","is-referenced-by-count":140,"title":["Perinatal hypoxic\u2014Ischemic thalamic injury: Clinical features and neuroimaging"],"prefix":"10.1002","volume":"44","author":[{"given":"Elke H.","family":"Roland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Poskitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Lupton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Neurology of the newborn","author":"Volpe JJ","year":"1995"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2779(1997)3:1<22::AID-MRDD4>3.0.CO;2-Z"},{"key":"e_1_2_1_4_2","first-page":"437","article-title":"Early pattern recognition in severe perinatal asphyxia: a prospective MRI study","volume":"35","author":"Baenziger OE","year":"1993","journal-title":"Neuro\u2010radiology"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1073021"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1542\/peds.87.4.431","article-title":"McArdle CB. 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