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Collateral flow via the ACoA and PCoA was determined with magnetic resonance angiography (MRA) and collateral flow via the OphA with transcranial Doppler (TCD). Volume flow was studied with MRA, metabolism with <jats:sup>1<\/jats:sup>H MR spectroscopy, CO<jats:sub>2<\/jats:sub> reactivity with TCD, and the incidence of border zone infarcts with MRI. Compared with controls, patients had deteriorated volume flow, metabolism, and CO<jats:sub>2<\/jats:sub> reactivity. No differences were found between patients with and patients without collateral flow through the ACoA and\/or PCoA, or between patients with or without collateral flow via the OphA. Patients without collateral flow via any of these collaterals had decreased volume flow in the middle cerebral artery, decreased <jats:bold>N<\/jats:bold>\u2010acetylaspartate\/choline, and increased lactate\/ <jats:bold>N<\/jats:bold>\u2010acetylaspartate, compared with the other patients. Patients with symptomatic internal carotid artery occlusion have deteriorated cerebral hemodynamics and metabolism. Different collateral flow patterns via the ACoA, PCoA, or OphA have no effect on the hemodynamic and metabolic parameters, as long as one of these pathways is present.<\/jats:p>","DOI":"10.1002\/ana.410440206","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:21:18Z","timestamp":1104592878000},"page":"167-176","source":"Crossref","is-referenced-by-count":97,"title":["Role of collateral flow on cerebral hemodynamics in patients with unilateral internal carotid artery occlusion"],"prefix":"10.1002","volume":"44","author":[{"given":"K. J.","family":"van Everdinge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. H.","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J. 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