{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:44:19Z","timestamp":1790934259353,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2229,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recently, \u03b1\u2010synuclein was shown to be a structural component of the filaments in Lewy bodies (LBs) of Parkinson's disease (PD), dementia with LBs (DLB) as well as the LB variant of Alzheimer's disease, and this suggests that \u03b1\u2010synuclein could play a mechanistic role in the pathogenesis of these disorders. To determine whether \u03b1\u2010synuclein is a building block of inclusions in other neurodegenerative movement disorders, we examined brains from patients with multiple system atrophy (MSA) and detected \u03b1\u2010synuclein, but not \u03b2\u2010 or \u03b3\u2010synuclein, in glial cytoplasmic inclusions (GCIs) throughout the MSA brain. In MSA white matter, \u03b1\u2010synuclein\u2013positive GCIs were restricted to oligodendrocytes, and \u03b1\u2010synuclein accumulated selectively in MSA white matter with \u03b1\u2010synuclein\u2013positive GCIs. Taken together with evidence that LBs contain insoluble \u03b1\u2010synuclein, our data suggest that a reduction in the solubility of \u03b1\u2010synuclein may induce this protein to form filaments that aggregate into cytoplasmic inclusions, which contribute to the dysfunction or death of glial cells as well as neurons in neurodegenerative disorders with different phenotypes.<\/jats:p>","DOI":"10.1002\/ana.410440324","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:21:43Z","timestamp":1104592903000},"page":"415-422","source":"Crossref","is-referenced-by-count":598,"title":["Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble \u03b1\u2010synuclein"],"prefix":"10.1002","volume":"44","author":[{"given":"Pang\u2010hsien","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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