{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:54:22Z","timestamp":1761393262754},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2199,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied eye movements and brainstem pathology in 2 patients with slow vertical saccades and autopsy\u2010proven amyotrophic lateral sclerosis (ALS). In both patients, the main ocular motor finding was supranuclear vertical gaze impairment with slow vertical saccades. The second patient had difficulty opening his eyes on command, with preserved spontaneous eyelid opening. Postmortem examination in both patients demonstrated cell loss in the rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF) and substantia nigra, along with histopathological findings consistent with ALS. The extent of the pathological changes in the riMLF corelated well with the degree of functional impairment as reflected in the slow vertical saccades. We suggest that motor neuron disease with early involvement of vertical saccades represents a distinct clinicopathological entity.<\/jats:p>","DOI":"10.1002\/ana.410440410","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:37:16Z","timestamp":1104597436000},"page":"641-648","source":"Crossref","is-referenced-by-count":67,"title":["Slow vertical saccades in motor neuron disease: Correlation of structure and function"],"prefix":"10.1002","volume":"44","author":[{"given":"Lea","family":"Averbuch\u2010Heller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Helmchen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja K. E.","family":"Horn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. John","family":"Leigh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean A.","family":"B\u00fcttner\u2010Ennever","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Principles of neurology","author":"Adams RD","year":"1993"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380109"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.6.2105"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.5.1037"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/BF00230482","article-title":"Oculomotor nuclear pathology in amyotrophic lateral sclerosis","volume":"85","author":"Okamoto K","year":"1993","journal-title":"Acta Neuropathol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(90)90165-J"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227663"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.8.1431-a"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(89)90158-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1992.tb03999.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1979.00500460049005"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160114"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00920622"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489409128318"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBMEL.1963.4322822"},{"key":"e_1_2_1_17_2","first-page":"801","article-title":"Upper eyelid premotor neurons in the rostral mesencephalon of the primate","volume":"22","author":"B\u00fcttner\u2010Ennever JA","year":"1996","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980323)392:4<413::AID-CNE1>3.0.CO;2-3"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90003-7"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90175-9"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90081-X"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90469-A"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90948-4"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00241117"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(95)00133-Y"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390314"},{"key":"e_1_2_1_27_2","volume-title":"The neurology of eye movements","author":"Leigh RJ","year":"1991"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1991.65.2.203"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1991.65.2.218"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.11.2015"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340215"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.2.547"},{"key":"e_1_2_1_33_2","volume-title":"Neurologic complications of cancer","author":"Posner JB","year":"1995"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410608"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.10.2031"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140103"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170518"},{"key":"e_1_2_1_38_2","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1523\/JNEUROSCI.14-04-02032.1994","article-title":"Neurotransmitter profile of saccadic omnipause neurons in nucleus raphe interpositus","volume":"14","author":"Horn AK","year":"1994","journal-title":"J Neurosci"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390519"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420211"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.0198"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960226)366:1<134::AID-CNE9>3.0.CO;2-4"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.6.1491"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.59.6.629"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.1.227"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410440410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410440410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T14:20:51Z","timestamp":1698502851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410440410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["10.1002\/ana.410440410"],"URL":"https:\/\/doi.org\/10.1002\/ana.410440410","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}