{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T23:03:25Z","timestamp":1776639805646,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":2138,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b2\u2010Trace protein concentrations in cerebrospinal fluid (CSF) and serum from 113 patients with variuos neurological diseases and 65 controls were determined with a sensitive and specific immunonephelometric assay. In adult control patients, \u03b2\u2010trace concentrations were 14.6 \u00b1 4.6 mg\/L in CSF and 0.46 \u00b1 0.13 mg\/L in serum, that is 32\u2010fold higher in CSF. \u03b2\u2010trace levels in CSF correlated with age as well as with the albumin CSF\/serum ratio (Q<jats:sub>A1b<\/jats:sub>), which is considered a measure for blood\u2010CSF barrier function. The relationship between CSF \u03b2\u2010trace levels and elevated Q<jats:sub>A1b<\/jats:sub> values was studied in various neurological diseases with CSF protein increase. In spinal canal stenosis, CSF \u03b2\u2010trace (mean = 29.5 \u00b1 10.5 mg\/L) correlated positively with increasing Q<jats:sub>A1b<\/jats:sub> values. In bacterial meningitis, CSF \u03b2\u2010trace (mean = 8.7 \u00b1 3.9 mg\/L) remained invariant to changes of Q<jats:sub>A1b<\/jats:sub> values. In Guillain\u2010Barre syndrome, CSF \u03b2\u2010trace (mean = 14.4 \u00b1 6.8 mg\/L) was below the Q<jats:sub>A1b<\/jats:sub>\u2010dependent reference range. In multiple sclerosis and viral meningoencephalitis, \u03b2\u2010trace levels were within the reference range. \u03b2\u2010Trace concentration in CSF can be used in conjunction with Q<jats:sub>A1b<\/jats:sub> to distinguish between different neurological pathologies associated with CSF protein increase.<\/jats:p>","DOI":"10.1002\/ana.410440606","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:27:51Z","timestamp":1104589671000},"page":"882-889","source":"Crossref","is-referenced-by-count":57,"title":["\u03b2\u2010Trace protein in cerebrospinal fluid: A blood\u2013CSF barrier\u2013related evaluation in neurological diseases"],"prefix":"10.1002","volume":"44","author":[{"given":"Hayrettin","family":"Tumanin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Nau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Felgenhauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(76)90259-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(87)90250-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00589509"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(94)90298-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-124-31897"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1971.9"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1972.tb07527.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb02145.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2297"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90179-O"},{"key":"e_1_2_1_12_2","first-page":"429","article-title":"Prostaglandin D synthase is the key enzyme in the promotion of physiological sleep","volume":"6","author":"Hayaishi O","year":"1993","journal-title":"J Lipid Mediat"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.3.1422"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199611)207:3<332::AID-AJA10>3.0.CO;2-6"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.37.3.302"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.19.9070"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12614-8"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-07-02376.1997"},{"key":"e_1_2_1_19_2","first-page":"B99","article-title":"Influence of CSF flow rate on \u03b2\u2010trace protein concentrations ventricular and lumber CSF. 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