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In this study, five doses (1 mg\/kg) of humanized anti\u2010Tac antibody were administered to 9 HAM\/TSP patients at weeks 0,2,6,10, and 14. Preliminary immunological studies on HAM\/TSP patients treated with humanized anti\u2010Tac indicate that there is a selective down\u2010regulation of activated T cells and a decrease in the HTLV\u2010I viral load in peripheral blood lymphocytes, most likely through the selective removal of HTLV\u2010I\u2013infected, activated CD4<jats:sup>+<\/jats:sup> lymphocytes.<\/jats:p>","DOI":"10.1002\/ana.410440613","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T14:27:51Z","timestamp":1104589671000},"page":"942-947","source":"Crossref","is-referenced-by-count":65,"title":["Reduction in HTLV\u2010I proviral load and spontaneous lymphoproliferation in HTLV\u2010I\u2013associated myelopathy\/tropical spastic paraparesis patients treated with humanized anti\u2010tac"],"prefix":"10.1002","volume":"44","author":[{"given":"Tanya J.","family":"Lehky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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