{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:46:17Z","timestamp":1790361977419,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    Reversing the aging process may yield significant benefits in people with multiple sclerosis (PwMS), as accelerated biological aging is observed in this population. Secondary analyses of 2 previously conducted dietary interventions including a 6\u2010month modified ketogenic diet in 39 participants and an 8\u2010week randomized comparison of intermittent and daily calorie restriction versus a weight\u2010stable regimen in 36 participants demonstrated significant decreases in metabolomic age (mAge) following the ketogenic diet (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009) and intermittent calorie restriction (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04), whereas daily calorie reduction had no effect. These findings indicate that fasting\u2010mimicking diets (FMDs) can reverse accelerated metabolomic aging in PwMS. 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