{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:18:34Z","timestamp":1785899914066,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001545","name":"Children's Tumor Foundation","doi-asserted-by":"publisher","award":["Drug Discovery Award \/ 2015\u201005\u2010010"],"award-info":[{"award-number":["Drug Discovery Award \/ 2015\u201005\u2010010"]}],"id":[{"id":"10.13039\/100001545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG\u2010MO1421\/5\u20101"],"award-info":[{"award-number":["DFG\u2010MO1421\/5\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Schwannomas are benign tumors that arise from Schwann cells of the nerve sheath, and their management presents a significant clinical challenge, particularly in genetic conditions like NF2\u2010related schwannomatosis (NF2\u2010SWN). Although current treatments, including surgery, radiation, and repurposed pharmacological agents, can be effective, they are often limited by issues such as tumor recurrence and the risk of nerve function impairment. This study aims to evaluate the potential of recombinant human Neuregulin1 beta 1 (rhNRG\u03b21) to inhibit schwannoma growth and promote Schwann cell differentiation in preclinical models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the therapeutic potential of rhNRG\u03b21, a recombinant human epidermal growth factor (EGF)\u2010like domain of Neuregulin1 beta 1, as a growth\u2010inhibitory agent for schwannomas. Two distinct mouse models were used to assess its efficacy, with both histological and functional endpoints analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both systemic and local administration of rhNRG\u03b21 resulted in a significant reduction in schwannoma tumor growth. Mechanistically, rhNRG\u03b21 not only inhibited tumor proliferation, but also promoted the differentiation of both proliferative and de\u2010differentiated Schwann cells, suggesting a dual action of growth inhibition and cellular maturation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>These findings highlight the therapeutic potential of rhNRG1\u2010\u03b21 in managing schwannomas, not only by reducing tumor growth, but also by promoting the maturation and functional restoration of Schwann cells. This dual effect provides a promising avenue for novel therapeutic strategies aimed at addressing both the growth and cellular differentiation challenges associated with schwannomas in NF2\u2010SWN and other related conditions. ANN NEUROL 2026;99:369\u2013381<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78050","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T11:53:27Z","timestamp":1760702007000},"page":"369-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Recombinant Human Neuregulin1\u2010\u03b21 Significantly Reduces Schwannoma Growth in Mice"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9915-5808","authenticated-orcid":false,"given":"Julia P.","family":"Bischoff","sequence":"first","affiliation":[{"name":"Leibniz Institute on Aging Fritz Lipmann Institute  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Schulz","sequence":"additional","affiliation":[{"name":"Leibniz Institute on Aging Fritz Lipmann Institute  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hagel","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"B\u00fcttner","sequence":"additional","affiliation":[{"name":"Leibniz Institute on Aging Fritz Lipmann Institute  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Reuter","sequence":"additional","affiliation":[{"name":"Leibniz Institute on Aging Fritz Lipmann Institute  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waylan K.","family":"Bessler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Herman B Wells Center for Pediatric Research Department of Biochemistry Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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