{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:53:43Z","timestamp":1793490823023,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLI 969\u2010B"],"award-info":[{"award-number":["KLI 969\u2010B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to investigate timing of occurrence of peri\u2010ictal MRI abnormalities \u2013 a potential risk biomarker of status epilepticus\u2010related cerebral injury (t2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study enrolled adult patients with status epilepticus and acute magnetic resonance imaging (MRI); patients with peri\u2010ictal MRI abnormalities underwent follow\u2010up MRI 4\u2009weeks later. Predictive model, using logistic regression, integrated clinical factors (duration, semiology, and etiology of status epilepticus and the patients\u2019 level of consciousness) to prognosticate occurrence of peri\u2010ictal MRI abnormalities. Cerebral injury due to status epilepticus was assessed by comparative volumetric analysis of acute and follow\u2010up MRIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 256 patients, 137 (53%) had peri\u2010ictal MRI abnormalities. The likelihood of their occurrence increased over time under the influence of semiology and etiology of status epilepticus as well as the patients\u2019 level of consciousness: it was highest in non\u2010convulsive status epilepticus caused by acute primary or secondary etiologies at 10\u2009minutes after onset in patients with stupor\/coma (81\u201385%); it increased at 24\u2009hours to 92%; and at 48\u2009hours to 95%. Conversely, in alert\/somnolent patients with prominent motor symptoms and acute triggering factors associated with epilepsy, the possibility of developing peri\u2010ictal MRI abnormalities at 24\u2009hours was 4 to 5% and at 48\u2009hours it was 6 to 11%. In 28 of 45 (62%) of follow\u2010up MRIs, structural long\u2010term consequences of status epilepticus were observed in the form of either cortical and hippocampal atrophy or global cerebral volume loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>In this novel multimodal approach based on MRI data, the patients\u2019 level of consciousness, etiology, and duration of status epilepticus offers insights into the risk of possible brain injury in status epilepticus. ANN NEUROL 2026;99:523\u2013534<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ana.78076","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T13:11:35Z","timestamp":1763989895000},"page":"523-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Timing of Peri\u2010Ictal\n                    <scp>MRI<\/scp>\n                    Abnormalities in Status Epilepticus \u2013 One Size Does Not Fit All"],"prefix":"10.1002","volume":"99","author":[{"given":"Pilar","family":"Bosque Varela","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Member of the European Reference Network EpiCARE Paracelsus Medical University of Salzburg  Salzburg 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